ArticleClinical research in cardiology : official journal of the German Cardiac Society2024
Heart rate variability: reference values and role for clinical profile and mortality in individuals with heart failure.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04064450 (MyoVasc - An Epidemiological Cohort Study to Investigate the Development and Progression of Heart Failure and the Interaction With Vascular Disease), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
MyoVasc - An Epidemiological Cohort Study to Investigate the Development and Progression of Heart Failure and the Interaction With Vascular Disease
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Heart rate variability as a dual-use digital biomarker: integrating clinical, AI, and operational perspectives on human performance and resilience.BMC cardiovascular disorders · 2026Pooled it
- The Impact on Autonomic Nervous System Activity during and Following Exercise in Adults: A Meta-Regression Study and Trial Sequential Analysis.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Article
- Autonomic impairment in advanced heart-failure patients revealed by nonlinear heart rate variability measured during exercise.Scientific reports · 2026Article
- Impact of Nonlinear Heart Rate Variability in Postoperative Complex Congenital Heart Disease: Insights From Repaired Tetralogy of Fallot and Fontan Palliation.Pediatric cardiology · 2026Article
- Circadian Activity Disruption in Cardiac Remodeling Patients Underlies Autonomic Dysfunction in Heart Failure.Biomedicines · 2026Article
- Correlation Analysis of 24-h Minimum Heart Rate Levels and Deceleration Capacity of Heart Rate in Patients With Type 2 Diabetes Mellitus Complicated With Essential Hypertension.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026Article
- Neurobiology of urological diseases.Current urology · 2026Review
- Exploring heart rate variability as a biomarker for frailty: A narrative review.European journal of clinical investigation · 2026Review
- Clustering-cum-regression based model and performance analysis for early prediction of heart disease.Scientific reports · 2026Article
- Reduced 24-hour heart rate variability in neurosyphilis: a retrospective case-control study.Frontiers in neurology · 2026Article
- Effect of bucladesine calcium combined with metoprolol on heart rate variability and cardiac function prognosis in heart failure patients with chronic arrhythmias.Frontiers in cardiovascular medicine · 2026Article
- Evaluation of Changes in Heart Rate Variability Associated with Puppy Growth Using Phase-Rectified Signal Averaging (PRSA) and Non-Gaussianity Index.Animals : an open access journal from MDPI · 2025Article
- Compensatory Failure of Autonomic Regulation in Phantom Limb Pain and Its Correlation with Maladaptive Plasticity: A Cross-Sectional HRV Study in Amputees.Biomedicines · 2025Article
- Deceleration Capacity as a Marker of Autonomic Cardiac Modulation in Prodromal and Manifest Parkinson's Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy.European journal of neurology · 2025Article
- Association of Heart Rate Variability and Acceleration Plethysmography with Systemic Comorbidity Burden in Patients with Glaucoma.Biomedicines · 2025Article
- Prognostic Value of the NT-proBNP-to-Albumin Ratio (NTAR) for In-Hospital Mortality in Chronic Heart Failure Patients.Biomedicines · 2025Article
- Parasympathetic response in women with coronary vascular dysfunction during mental stress compared to those with non-cardiac chest pain and reference controls.International journal of cardiology. Heart & vasculature · 2025Article
- Heart Rate Variability and Autonomic Dysfunction After Stroke: Prognostic Markers for Recovery.Biomedicines · 2025Review
- A new approach to interpreting the LF/HF ratio: a study in hypertensive patients.Journal of human hypertension · 2025Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
Abstract
aimsTo establish reference values and clinically relevant determinants for measures of heart rate variability (HRV) and to assess their relevance for clinical outcome prediction in individuals with heart failure.
methodsData from the MyoVasc study (NCT04064450; N = 3289), a prospective cohort on chronic heart failure with a highly standardized, 5 h examination, and Holter ECG recording were investigated. HRV markers were selected using a systematic literature screen and a data-driven approach. Reference values were determined from a healthy subsample. Clinical determinants of HRV were investigated via multivariable linear regression analyses, while their relationship with mortality was investigated by multivariable Cox regression analyses.
resultsHolter ECG recordings were available for analysis in 1001 study participants (mean age 64.5 ± 10.5 years; female sex 35.4%). While the most frequently reported HRV markers in literature were from time and frequency domains, the data-driven approach revealed predominantly non-linear HRV measures. Age, sex, dyslipidemia, family history of myocardial infarction or stroke, peripheral artery disease, and heart failure were strongly related to HRV in multivariable models. In a follow-up period of 6.5 years, acceleration capacity [HR
conclusionHRV markers are associated with the cardiovascular clinical profile and are strong and independent predictors of survival in heart failure. This underscores clinical relevance and interventional potential for individuals with heart failure. CLINICALTRIALS: GOV IDENTIFIER: NCT04064450.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.