ArticleCell reports2023
AgRP neurons are not indispensable for body weight maintenance in adult mice.
Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Article
- Obesity Disrupts CtBP2-Mediated Maintenance of Transcriptional Equilibrium in Hypothalamic Feeding Circuitry.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Reduced melanocortin tone modulates feeding during pregnancy in mice.Nature communications · 2026Article
- An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feeding.Metabolism: clinical and experimental · 2026Article
- Emerging role of AgRP neurons as integrators of metabolic, sensory and environmental cues in the control of energy homeostasis.Reviews in endocrine & metabolic disorders · 2026Review
- Selective and differential roles of PVHNature communications · 2026Article
- GLP-1 physiology and pharmacology along the gut-brain axis.The Journal of clinical investigation · 2026Review
- Comprehensive insights into emerging advances in the Neurobiology of anorexia.Journal of advanced research · 2026Review
- An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feeding.bioRxiv : the preprint server for biology · 2025Article
- Trigeminal root demyelination is sufficient to induce trigeminal neuralgia-like facial pain in adult rodents.The journal of headache and pain · 2025Article
- A hypothalamic circuit for anticipating future changes in energy balance.bioRxiv : the preprint server for biology · 2025Article
- AgRP neuron activity enhances reward-related consummatory behaviors during energy deficit in mice.Communications biology · 2025Article
- Regulation of Feeding Behavior and Body Weight by Orexigenic Neurons in the Arcuate Nucleus.Journal of obesity & metabolic syndrome · 2025Review
- Angiotensin ATiScience · 2025Article
- Neuroendocrinology and the Genetics of Obesity.Endocrinology · 2025Review
- Molecular mechanisms and neural mediators of leptin action.Genes & development · 2025Review
- Postnatal hyperosmolality alters development of hypothalamic feeding circuits with context-specific changes in ingestive behavior.iScience · 2025Article
- AgRP neuron hyperactivity drives hyperglycemia in a mouse model of type 2 diabetes.The Journal of clinical investigation · 2025Article
- Neuronal Regulation of Feeding and Energy Metabolism: A Focus on the Hypothalamus and Brainstem.Neuroscience bulletin · 2025Review
- Systemic Glucose Homeostasis Requires Pancreatic but Not Neuronal ATP-sensitive Potassium Channels.Function (Oxford, England) · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
In addition to their role in promoting feeding and obesity development, hypothalamic arcuate agouti-related protein/neuropeptide Y (AgRP/NPY) neurons are widely perceived to be indispensable for maintaining normal feeding and body weight in adults, and consistently, acute inhibition of AgRP neurons is known to reduce short-term food intake. Here, we adopted complementary methods to achieve nearly complete ablation of arcuate AgRP/NPY neurons in adult mice and report that lesioning arcuate AgRP/NPY neurons in adult mice causes no apparent alterations in ad libitum feeding or body weight. Consistent with previous studies, loss of AgRP/NPY neurons blunts fasting refeeding. Thus, our studies show that AgRP/NPY neurons are not required for maintaining ad libitum feeding or body weight homeostasis in adult mice.
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Registered trials
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