ArticleAllergy2023
Shotgun metagenomic sequencing on skin microbiome indicates dysbiosis exists prior to the onset of atopic dermatitis.
Article in Allergy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The trial behind it
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Understanding Infantile Atopic Dermatitis: A Review of Environmental, Familial, Genetic and Microbial Influences.Current allergy and asthma reports · 2026Review
- P.A.D.D.L.E.: a hypothesis generation tool for assessing pollution's potential role in disease.Scientific reports · 2026Article
- Article
- Reply to Brown and Burleigh's "Molecular and Cellular Mechanisms Leading to Topical Steroid Withdrawal Syndrome Remain Unexplained and Warrant Further Research".The Journal of investigative dermatology · 2025Article
- Targeting Pollutants in the Treatment and Prevention of Atopic Dermatitis.Immunology and allergy clinics of North America · 2025Review
- Distinct gut microbiome shifts in the NICU influence later atopic dermatitis development.medRxiv : the preprint server for health sciences · 2025Article
- Topical Steroid Withdrawal Is a Targetable Excess of Mitochondrial NAD.The Journal of investigative dermatology · 2025Article
- Skin imaging mass spectrometry of controls versus atopic dermatitis patients with and withoutiScience · 2025Article
- Skin and systemic infections in children with atopic dermatitis: review of the current evidence.Frontiers in pediatrics · 2025Review
- Environmental and behavioral mitigation strategies for patients with atopic dermatitis.JAAD international · 2024Article
- Characterization of the Gut and Skin Microbiome over Time in Young Children with IgE-Mediated Food Allergy.Nutrients · 2024Article
- The clinical, mechanistic, and social impacts of air pollution on atopic dermatitis.The Journal of allergy and clinical immunology · 2024Review
- Atopic Dermatitis and Psoriasis: Similarities and Differences in Metabolism and Microbiome.Clinical reviews in allergy & immunology · 2024Review
- Does "all disease begin in the gut"? The gut-organ cross talk in the microbiome.Applied microbiology and biotechnology · 2024Review
- Spatial modeling connecting childhood atopic dermatitis prevalence with household exposure to pollutants.Communications medicine · 2024Article
- The Skin Microbiome and its Significance for Dermatologists.American journal of clinical dermatology · 2024Article
- Vaginal delivery provides skin colonization resistance from environmental microbes in the NICU.Clinical and translational medicine · 2023Article
- Update on the pathogenesis of atopic dermatitis.Anais brasileiros de dermatologiaReview
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundWhile the microbiome is increasingly seen as a targetable contributor to atopic dermatitis (AD), questions remain as to whether the dysbiosis is secondary to diseased skin or if it predates symptom onset. Previous work has evaluated how the skin microbiome changes with age and established the influence of factors like delivery mode and breastfeeding on global microbiome diversity. However, these studies were unable to identify taxa which predict subsequent AD.
methodsSkin swab samples were collected from the first week of life for 72 children in the neonatal intensive care unit (NICU) at a single site hospital. Participants were followed for 3 years to determine their health status. We applied shotgun metagenomic sequencing to assess the microbiome differences between 31 children who went on to develop AD and 41 controls.
resultsWe identified that subsequent development of AD was associated with differential abundance of several bacterial and fungal taxa as well as several metabolic pathways, each of which have been previously associated with active AD.
conclusionsOur work provides evidence of reproducibility for the previously reported dysbiotic signatures predating AD onset while also expanding prior findings through the first use of metagenomic assessment prior to AD onset. While extrapolation of our findings beyond the pre-term, NICU cohort is limited, our findings add to the evidence that the dysbiosis associated with AD pre-dates disease onset rather than reflect a secondary consequence of skin inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.