Evidence map›Paper›PMID 37422617›Full record

ArticleBMC oral health2023

CD8 + T-cell marker genes reveal different immune subtypes of oral lichen planus by integrating single-cell RNA-seq and bulk RNA-sequencing.

Jinhao Zhang, Gaoge Peng, Hao Chi, Jinyan Yang, Xixi Xie, Guobin Song, Lisa Jia Tran, Zhijia Xia, Gang Tian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jinhao Zhang *School of Stomatology, Southwest Medical University, Luzhou, China.
Gaoge Peng *Clinical Medical College, Southwest Medical University, Luzhou, China.
Hao Chi *Clinical Medical College, Southwest Medical University, Luzhou, China.
Jinyan YangSchool of Stomatology, Southwest Medical University, Luzhou, China.
Xixi XieSchool of Stomatology, Southwest Medical University, Luzhou, China.
Guobin SongSchool of Stomatology, Southwest Medical University, Luzhou, China.
Lisa Jia TranDepartment of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany.
Zhijia XiaDepartment of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany. Zhijia.Xia@med.uni-muenchen.de.
Gang TianDepartment of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China. tiangang@swmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOral lichen planus (OLP) is a local autoimmune disease induced by T-cell dysfunction that frequently affects middle-aged or elderly people, with a higher prevalence in women. CD8 + T cells, also known as killer T cells, play an important role in the progression and persistence of OLP. In order to identify different OLP subtypes associated with CD8 + T cell pathogenesis, consensus clustering was used.

methodsIn this study, we preprocessed and downscaled the OLP single-cell dataset GSE211630 cohort downloaded from Gene Expression Omnibus (GEO) to finally obtain the marker genes of CD8 + T cells. Based on the expression of marker genes, we classified OLP patients into CMGs subtypes using unsupervised clustering analysis. The gene expression profiles were analyzed by WGCNA using the "WGCNA" R package based on the clinical disease traits and typing results, and 108 CD8 + T-cell related OLP pathogenicity-related genes were obtained from the intersection. Patients were once again classified into gene subtypes based on intersection gene expression using unsupervised clustering analysis.

resultsAfter obtaining the intersecting genes of CD8 + T cells related to pathogenesis, OLP patients can be precisely classified into two different subtypes based on unsupervised clustering analysis, and subtype B has better immune infiltration results, providing clinicians with a reference for personalized treatment.

conclusionsClassification of OLP into different subtypes improve our current understanding of the underlying pathogenesis of OLP and provides new insights for future studies.

Indexed as

Lichen Planus, OralAgedCD8-Positive T-LymphocytesFemaleHumansMiddle AgedRNASingle-Cell Gene Expression AnalysisRNAAutoimmunityCD8 + T cellsOLPSingle-cell sequencingUnsupervised hierarchical clustering

Identifiers

PMID37422617
PMCPMC10329325

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.