Evidence map›Paper›PMID 37422456›Full record

ArticleScientific reports2023

Arteriovenous malformation Map2k1 mutation affects vasculogenesis.

Christopher L Sudduth, Patrick J Smits, Matthew P Vivero, Yu Sheng Cheng, Michal Ad, Dennis J Konczyk, Joyce Bischoff, Matthew L Warman, Arin K Greene

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Translational relevance of animal models available on brain arteriovenous malformations, a systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Christopher L SudduthDepartment of Plastic and Oral Surgery, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA.
Patrick J SmitsDepartment of Plastic and Oral Surgery, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA.
Matthew P ViveroDepartment of Plastic and Oral Surgery, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA.
Yu Sheng ChengDepartment of Plastic and Oral Surgery, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA.
Michal AdDepartment of Plastic and Oral Surgery, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA.
Dennis J KonczykDepartment of Plastic and Oral Surgery, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA.
Joyce BischoffVascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Matthew L WarmanDepartment of Orthopedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Arin K GreeneDepartment of Plastic and Oral Surgery, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA. arin.greene@childrens.harvard.edu.
Boston Children's Hospital · US

Funding

Determining the pathophysiology of pediatric arteriovenous malformationR01HD093735 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI GREENE, ARIN K. · 2018 to 2022
$3.5M
Pediatric Surgeon-Scientist Training Program in Vascular DiseasesT32HD104582 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Joyce E. Bischoff, Arin K. Greene · 2022 to 2026
$1.1M
NICHD NIH HHS R01 HD093735NICHD NIH HHS T32 HD104582
6 · The paper itself

Abstract

Somatic activating MAP2K1 mutations in endothelial cells (ECs) cause extracranial arteriovenous malformation (AVM). We previously reported the generation of a mouse line allowing inducible expression of constitutively active MAP2K1 (p.K57N) from the Rosa locus (R26

Indexed as

Arteriovenous MalformationsVascular MalformationsAnimalsEndothelial CellsMAP Kinase Kinase 1MiceMutationMap2k1 protein, mouseMAP Kinase Kinase 1

Identifiers

PMID37422456
PMCPMC10329712
OpenAlexW4383619311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.