ArticleCurrent biology : CB2023
Synaptic variance and action potential firing of cerebellar output neurons during motor learning in larval zebrafish.
Article in Current biology : CB, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 citing papers in PubMed, 9 citations in OpenAlex.
- Critical period plasticity enables credit assignment.bioRxiv : the preprint server for biology · 2026Article
- The cerebellum implements structured representation of valence to support adaptive behavior control.Science advances · 2026Article
- Coordination of spike timing among the neurons of the cerebellum.Research square · 2026Article
- Zebrafish as a translational model for peptide-mediated synaptic dysfunction related to obesity.Frontiers in synaptic neuroscience · 2026Review
- Coordination of spike timing among the neurons of the cerebellum.bioRxiv : the preprint server for biology · 2025Article
- Article
- Cerebellar Purkinje Cells Control Posture in Larval Zebrafish (bioRxiv : the preprint server for biology · 2024Article
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3 authors at 1 institution in 1 country.
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Abstract
The cerebellum regulates both reflexive and acquired movements. Here, by recording voltage-clamped synaptic currents and spiking in cerebellar output (eurydendroid) neurons in immobilized larval zebrafish, we investigated synaptic integration during reflexive movements and throughout associative motor learning. Spiking coincides with the onset of reflexive fictive swimming but precedes learned swimming, suggesting that eurydendroid signals may facilitate the initiation of acquired movements. Although firing rates increase during swimming, mean synaptic inhibition greatly exceeds mean excitation, indicating that learned responses cannot result solely from changes in synaptic weight or upstream excitability that favor excitation. Estimates of spike threshold crossings based on measurements of intrinsic properties and the time course of synaptic currents demonstrate that noisy excitation can transiently outweigh noisy inhibition enough to increase firing rates at swimming onset. Thus, the millisecond-scale variance of synaptic currents can regulate cerebellar output, and the emergence of learned cerebellar behaviors may involve a time-based code.
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