ArticleCell reports. Medicine2023
Coordinated human sleeping brainwaves map peripheral body glucose homeostasis.
Article in Cell reports. Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Mulberry leaf extract combined with tryptophan improves sleep and post wake mood in adults with sleep complaints - A randomized cross-over study.European journal of nutrition · 2025Trial
- Chronic REM Sleep Deprivation Induces Metabolic and Neurotoxic Alterations Associated with Affective and Cognitive Deficit in Male Wistar Rats: Involvement of HPA Axis, Cholinergic, Inflammatory, and Oxidative Stress Pathways.Neurochemical research · 2026Article
- A pilot study testing a continuous glucose monitoring sensor in lean growing pigs fed contrasting diets, to document nocturnal and diurnal glycemic excursions as well as their relationships.Veterinary and animal science · 2026Review
- Sleep Efficiency Predicts Next-Day Glycaemia and Daytime Glycaemia Influences Sleep in Free-Living Adults at Risk of Type 2 Diabetes.Diabetes, obesity & metabolism · 2026Observational
- Model Analysis of the American Heart Association's Life's Essential 8: Can Physical Activity Mitigate Cardiovascular Risk Among Low-Income Individuals?Journal of the American Heart Association · 2026Article
- SleepJEPA: Learning the latent world of sleep with at-home sleep data to estimate disease risk.medRxiv : the preprint server for health sciences · 2026Article
- Linking sleep microstructure, blood markers of inflammation and metabolism, and cognition: mediation analysis in the osteoporotic fractures in men study.GeroScience · 2026Article
- A multimodal sleep foundation model for disease prediction.Nature medicine · 2026Article
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- Stimulating the Stimulated Cortex-Frontocortical Anodal Electric Stimulation Combined With Closed-Loop Acoustic Stimulation During Sleep Impairs Memory in Subjects With High Cognitive Ability.The European journal of neuroscience · 2025Article
- The Future of Automated Insulin Delivery Systems.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2025Review
- Phase-Amplitude Coupling in Sleep EEG-Stable Trait or Shaped by Experience? (Commentary on Cross et al., 2025).The European journal of neuroscience · 2025Article
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- Artificial Intelligence Can Drive Sleep Medicine.Sleep medicine clinics · 2025Review
- A Multimodal Sleep Foundation Model Developed with 500K Hours of Sleep Recordings for Disease Predictions.medRxiv : the preprint server for health sciences · 2025Article
- Violet light could improve sleep quality and blood glucose levels in healthy individuals: A pilot study.PloS one · 2025Article
- Increased relative abundance ofFrontiers in sleep · 2025Article
- Differences in brain spindle density during sleep between patients with and without type 2 diabetes.Computers in biology and medicine · 2025Article
- Differences in sleep spindle wave density between patients with diabetes mellitus and matched controls: implications for sensing and regulation of peripheral blood glucose.medRxiv : the preprint server for health sciences · 2024Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
Insufficient sleep impairs glucose regulation, increasing the risk of diabetes. However, what it is about the human sleeping brain that regulates blood sugar remains unknown. In an examination of over 600 humans, we demonstrate that the coupling of non-rapid eye movement (NREM) sleep spindles and slow oscillations the night before is associated with improved next-day peripheral glucose control. We further show that this sleep-associated glucose pathway may influence glycemic status through altered insulin sensitivity, rather than through altered pancreatic beta cell function. Moreover, we replicate these associations in an independent dataset of over 1,900 adults. Of therapeutic significance, the coupling between slow oscillations and spindles was the most significant sleep predictor of next-day fasting glucose, even more so than traditional sleep markers, relevant to the possibility of an electroencephalogram (EEG) index of hyperglycemia. Taken together, these findings describe a sleeping-brain-body framework of optimal human glucose homeostasis, offering a potential prognostic sleep signature of glycemic control.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.