Evidence map›Paper›PMID 37421537›Full record

ArticleClinical rheumatology2023

Risk factors and prognosis of interstitial lung disease for primary Sjögren syndrome patients: A retrospective case‒control study.

Yichen Huang, Yanran Qiu, Zhijun Xie, Fengqi Zhang, Yi Zhang, Meihui Guan, Xinchang Wang, Wanru Cai, Jing Sun

Abstract read
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In one paragraph

Article in Clinical rheumatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. The analysis of the pulmonary domain involvement in Sjögren's disease.Therapeutic advances in musculoskeletal disease · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yichen Huang *The Second Clinical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Yanran Qiu *The Second Clinical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Zhijun Xie *School of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Fengqi ZhangSchool of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Yi ZhangSchool of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Meihui GuanThe Second Clinical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Xinchang WangThe Second Clinical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. ossani@126.com.
Wanru CaiThe Second Clinical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. caiwanru@aliyun.com.
Jing SunThe Second Clinical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. tomorrow123go@163.com.ORCID http://orcid.org/0000-0001-9616-7320
Zhejiang Chinese Medical University · CN

Funding

Natural Science Foundation of Zhejiang Province Y21H270014Science and Technology Program of Zhejiang 2020ZZ006Science and Technology Program of Zhejiang Province Y202146162
6 · The paper itself

Abstract

objectiveTo determine the prevalence, clinical features, risk factors, and prognosis of interstitial lung disease (ILD) in patients with primary Sjogren's syndrome (pSS).

methodsData from 274 pSS patients from August 2013 to August 2022 were reviewed. The clinical features of pSS with ILD were revealed. Logistic regression was used to determine risk factors for ILD in pSS patients. Survival analysis and Cox regression were used to analyse the prognosis and prognostic factors of pSS patients.

resultsIn pSS patients, the prevalence of ILD was 22.3% (61/274). The pSS patients with ILD were characterized by a late onset and long disease course, with a nonspecific interstitial pneumonia (NSIP) pattern as the predominant high-resolution computed tomography (HRCT) finding. Logistic regression results indicated that an age over 50 years old (OR 4.786, 95% CI 1.602-14.299; P = 0.005), purpuric rash (OR 4.695, 95% CI 1.537-14.339; P = 0.007), AMA-M2 antibody positivity (OR 2.582, 95% CI 1.166-5.722; P = 0.019), and diabetes (OR 2.514, 95% CI 1.025-6.167; P = 0.044) were risk factors for ILD in pSS patients. Cox regression results showed that advanced age (HR 1.240, 95% CI 1.088-1.413; P = 0.001) and cancer history (HR 8.411, 95% CI 1.771-39.934; P = 0.007) were risk factors for pSS patient survival.

conclusionThis study showed that pSS patients with ILD tended to have a late onset and long course of pSS. An age over 50 years, purpuric rash, AMA-M2 antibody positivity, and diabetes were risk factors for ILD in pSS patients. Advanced age and cancer history were prognostic factors in pSS patients. Key Points • This study showed that pSS patients with ILD tended to have a late-onset and lengthy course of pSS, with the NSIP pattern as the predominant lung image. • The risk factors for ILD in pSS patients determined in this study were an age over 50 years, purpuric rash, AMA-M2 antibody positivity, and diabetes. • The prognostic risk factors for pSS patients were advanced age and cancer history.

Indexed as

Diabetes MellitusExanthemaIdiopathic Interstitial PneumoniasLung Diseases, InterstitialNeoplasmsSjogren's SyndromeAntibodiesCase-Control StudiesHumansLungMiddle AgedPrognosisRetrospective StudiesRisk FactorsAntibodiesCase‒control studyInterstitial lung diseasePrimary Sjögren syndromeRisk factor

Identifiers

PMID37421537
OpenAlexW4383645868

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.