Evidence map›Paper›PMID 37421466›Full record

ArticleJournal of neurology2023

The rising role of cognitive reserve and associated compensatory brain networks in spinocerebellar ataxia type 2.

Libera Siciliano, Giusy Olivito, Nicole Urbini, Maria Caterina Silveri, Maria Leggio

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Libera SicilianoDepartment of Psychology, Sapienza University of Rome, 00185, Rome, Italy.
Giusy OlivitoDepartment of Psychology, Sapienza University of Rome, 00185, Rome, Italy.
Nicole UrbiniDepartment of Psychology, Sapienza University of Rome, 00185, Rome, Italy.
Maria Caterina SilveriDepartment of Psychology, Catholic University of the Sacred Heart, 20123, Milan, Italy.
Maria LeggioDepartment of Psychology, Sapienza University of Rome, 00185, Rome, Italy. maria.leggio@uniroma1.it.ORCID http://orcid.org/0000-0003-3750-2760
Fondazione Santa Lucia · ITUniversità Cattolica del Sacro Cuore · IT

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca 20203LT7H3Sapienza Università di Roma RG120172B8343252
6 · The paper itself

Abstract

Pre-existing or enhanced cognitive abilities influence symptom onset and severity in neurodegenerative diseases, which improve an individual's ability to deal with neurodegeneration. This process is named cognitive reserve (CR), and it has acquired high visibility in the field of neurodegeneration. However, the investigation of CR has been neglected in the context of cerebellar neurodegenerative disorders. The present study assessed CR and its impact on cognitive abilities in spinocerebellar ataxia type 2 (SCA2), which is a rare cerebellar neurodegenerative disease. We investigated the existence of CR networks in terms of compensatory mechanisms and neural reserve driven by increased cerebello-cerebral functional connectivity. The CR of 12 SCA2 patients was assessed using the Cognitive Reserve Index Questionnaire (CRIq), which was developed for appraising life-span CR. Patients underwent several neuropsychological tests to evaluate cognitive functioning and a functional MRI examination. Network based statistics analysis was used to assess functional brain networks. The results revealed significant correlations of CRIq measures with cognitive domains and patterns of increased connectivity in specific cerebellar and cerebral regions, which likely indicated CR networks. This study showed that CR may influence disease-related cognitive deficits, and it was related to the effective use of specific cerebello-cerebral networks that reflect a CR biomarker.

Indexed as

Cognitive ReserveSpinocerebellar AtaxiasBrainCerebellumHumansMagnetic Resonance ImagingNeuropsychological TestsCerebellumCognitive functioningCompensation mechanismsFunctional connectivityNBSSCA2

Identifiers

PMID37421466
PMCPMC10511586
OpenAlexW4383620039

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.