Evidence map›Paper›PMID 37421433›Full record

ArticleLung2023

A Longitudinal Study of Respiratory Mechanics in Pregnant Women with Obesity and Overweight.

Ghada Bourjeily, Laura Sanapo, Geralyn Messerlian, Margaret H Bublitz, Beth Hott, Melissa Guillen, Annaly Aldana, Ashanti Avalos, Tamara Sequeira, Cheryl Felber and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Lung, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Ghada BourjeilyDepartment of Medicine, Warren Alpert Medical School of Brown University, Providence, RI, 02903, USA. ghada_bourjeily@brown.edu.ORCID 0000-0002-0543-4719
Laura SanapoDepartment of Medicine, Warren Alpert Medical School of Brown University, Providence, RI, 02903, USA.
Geralyn MesserlianDepartments of Obstetrics and Gynecology and Pathology and Laboratory Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA.
Margaret H BublitzWomen's Medicine Collaborative, The Miriam Hospital, 146 West River St., Providence, RI, 02904, USA.
Beth HottWomen's Medicine Collaborative, The Miriam Hospital, 146 West River St., Providence, RI, 02904, USA.
Melissa GuillenWomen's Medicine Collaborative, The Miriam Hospital, 146 West River St., Providence, RI, 02904, USA.
Annaly AldanaWomen's Medicine Collaborative, The Miriam Hospital, 146 West River St., Providence, RI, 02904, USA.
Ashanti AvalosWomen's Medicine Collaborative, The Miriam Hospital, 146 West River St., Providence, RI, 02904, USA.
Tamara SequeiraWomen's Medicine Collaborative, The Miriam Hospital, 146 West River St., Providence, RI, 02904, USA.
Cheryl FelberDepartment of Pathology and Laboratory Medicine, Women and Infants Hospital, 101 Dudley St., Providence, RI, 02905, USA.
Cynthia BrosnanWomen's Medicine Collaborative, The Miriam Hospital, 146 West River St., Providence, RI, 02904, USA.
Talal El ZarifHarvard Medical School, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
F Dennis McCoolDepartment of Medicine, Warren Alpert Medical School of Brown University, Providence, RI, 02903, USA.
Miriam Hospital · USBrown University · USHarvard University · USProvidence College · US

Funding

Uncoupling of IL-1 beta and VEGF-A Crosstalk Contributes to Impaired Arteriogenesis Response to Ischemia in Chronic Diabetes MellitusP20GM103652 · NIGMS · OCEAN STATE RESEARCH INSTITUTE, INC. · PI HARRINGTON, ELIZABETH O · 2013 to 2022
$21.3M
Mechanisms of mindfulness training to prevent hypertensive disorders of pregnancyR01HL157288 · NHLBI · MIRIAM HOSPITAL · PI BUBLITZ, MARGARET · 2021 to 2025
$2.8M
Placental role in mediating adverse outcomes in obstructive sleep apneaR01HD078515 · NICHD · MIRIAM HOSPITAL · PI BOURJEILY, GHADA · 2014 to 2018
$2.7M
Predictors of de novo development of obstructive sleep apnea in pregnancyR01HL130702 · NHLBI · MIRIAM HOSPITAL · PI BOURJEILY, GHADA · 2016 to 2020
$2.6M
NHLBI NIH HHS R01HL130702NHLBI NIH HHS R01HL157288NICHD NIH HHS R01 HD078515NIGMS NIH HHS 5P20GM103652
6 · The paper itself

Abstract

purposeRespiratory mechanics and the role of sex hormones in pregnancy are not well elucidated. We examined longitudinal and positional changes in lung mechanics in pregnancy and investigated the role of sex hormones.

methodsA longitudinal study enrolled 135 women with obesity in early pregnancy. Fifty-nine percent of women identified as White; median body mass index at enrollment was 34.4 kg/m

resultsWith pregnancy progression, there was a significant increase in resonant frequency (Fres) (p = 0.012), integrated area of low frequency reactance (AX) (p = 0.0012) and R5-R20Hz (p = 0.038) in the seated position, and a significant increase in R5Hz (p = 0.000), Fres (p = 0.001), AX (p < 0.001 = 0.000), and R5-R20Hz (p = 0.014) in the supine position. Compared to the seated position, the supine position was associated with a significant increase in R5Hz, R20Hz, X5Hz, Fres, and AX in early (p-values < 0.026) and late pregnancy (p-values ≤ 0.001). Changes in progesterone levels between early and late pregnancy predicted the change in R5, Fres, and AX (p-values ≤ 0.043).

conclusionResistive and elastic loads increase with pregnancy progression and a change in body position from seated to supine increases resistive and elastic loads in both early and late pregnancies. The increase in airway resistance is primarily related to an increase in peripheral rather than central airways resistance. There was an association between the change in progesterone levels and airway resistance.

Indexed as

OverweightPregnant PeopleAirway ResistanceFemaleHumansLongitudinal StudiesLungObesityPregnancyProgesteroneRespiratory MechanicsSpirometryProgesteroneAirway resistancePregnancyRespiratory physiologyRespiratory system reactance

Identifiers

PMID37421433
OpenAlexW4383620637

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.