Evidence map›Paper›PMID 37421402›Full record

ArticleInterdisciplinary cardiovascular and thoracic surgery2023

Concomitant left atrial appendage closure during left ventricular assist device surgery can reduce ischaemic cerebrovascular accidents.

Hidefumi Nishida, Valluvan Jeevanandam, Christopher Salerno, Atsushi Nemoto, Tae Song, David Onsager, Ann Nguyen, Jonathan Grinstein, Bow Chung, Nitasha Sarswat and 3 more

Erratum issuedOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Interdisciplinary cardiovascular and thoracic surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Hidefumi NishidaDepartment of Surgery, University of Chicago Medicine, Chicago, IL, USA.
Valluvan JeevanandamDepartment of Surgery, University of Chicago Medicine, Chicago, IL, USA.
Christopher SalernoDepartment of Surgery, University of Chicago Medicine, Chicago, IL, USA.
Atsushi NemotoDepartment of Surgery, University of Chicago Medicine, Chicago, IL, USA.
Tae SongDepartment of Surgery, University of Chicago Medicine, Chicago, IL, USA.
David OnsagerDepartment of Surgery, University of Chicago Medicine, Chicago, IL, USA.
Ann NguyenDepartment of Medicine, University of Chicago Medicine, Chicago, IL, USA.
Jonathan GrinsteinDepartment of Medicine, University of Chicago Medicine, Chicago, IL, USA.
Bow ChungDepartment of Medicine, University of Chicago Medicine, Chicago, IL, USA.
Nitasha SarswatDepartment of Medicine, University of Chicago Medicine, Chicago, IL, USA.
Gene KimDepartment of Medicine, University of Chicago Medicine, Chicago, IL, USA.
Sean PinneyDepartment of Medicine, University of Chicago Medicine, Chicago, IL, USA.
Takeyoshi OtaDepartment of Surgery, University of Chicago Medicine, Chicago, IL, USA.
University of Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIt remains unknown if the left atrial appendage closure (LAAC) at the time of left ventricular assist device (LVAD) surgery can reduce ischaemic cerebrovascular accidents.

methodsConsecutive 310 patients who underwent LVAD surgery with HeartMate II or 3 between January 2012 and November 2021 were included in this study. The cohort was divided into 2 groups: patients with LAAC (group A) and without LAAC (group B). We compared the clinical outcomes including the incidence of cerebrovascular accident between 2 groups.

resultsNinety-eight patients were included in group A, and 212 patients in group B. There were no significant differences between 2 groups in age, preoperative CHADS2 score and history of atrial fibrillation. In-hospital mortality did not differ significantly between the 2 groups (group A: 7.1%, group B: 12.3%, P = 0.16). Thirty-seven patients (11.9%) experienced ischaemic cerebrovascular accident (5 patients in group A and 32 patients in group B). The cumulative incidence from ischaemic cerebrovascular accidents in group A (5.3% at 12 months and 5.3% at 36 months) was significantly lower than that in group B (8.2% at 12 months and 16.8% at 36 months; P = 0.017). In a multivariable competing risk analysis, LAAC was associated with reducing ischaemic cerebrovascular accidents (hazard ratio 0.38, 95% confidence interval 0.15-0.97, P = 0.043).

conclusionsConcomitant LAAC in LVAD surgery can reduce ischaemic cerebrovascular accidents without increasing perioperative mortality and complications.

Indexed as

Ischaemic cerebrovascular accidentLeft atrial appendage closureLeft ventricular assist device

Identifiers

PMID37421402
PMCPMC10338136
OpenAlexW4383646038

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.