Evidence map›Paper›PMID 37421267›Full record

ArticleJournal of the American Heart Association2023

Distinct Effects of Mitochondrial Na

Sathya Velmurugan, Ting Liu, Kuey C Chen, Florin Despa, Brian O'Rourke, Sanda Despa

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Increased Intermembrane Space [CaCirculation research · 2025
    Article
  5. Review
  6. Review
  7. Role of AMP deaminase in diabetic cardiomyopathy.Molecular and cellular biochemistry · 2024
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sathya VelmuruganDepartment of Pharmacology and Nutritional Sciences University of Kentucky Lexington KY USA.ORCID 0000-0003-0769-8424
Ting LiuDivision of Cardiology, Department of Medicine The Johns Hopkins University Baltimore MD USA.ORCID 0000-0002-8304-5751
Kuey C ChenDepartment of Pharmacology and Nutritional Sciences University of Kentucky Lexington KY USA.ORCID 0000-0002-6980-8310
Florin DespaDepartment of Pharmacology and Nutritional Sciences University of Kentucky Lexington KY USA.ORCID 0000-0002-5879-6449
Brian O'RourkeDivision of Cardiology, Department of Medicine The Johns Hopkins University Baltimore MD USA.ORCID 0000-0002-5548-4853
Sanda DespaDepartment of Pharmacology and Nutritional Sciences University of Kentucky Lexington KY USA.ORCID 0000-0002-2374-6177
University of Kentucky · USJohns Hopkins University · US

Funding

The Amylin Dyshomeostasis Hypothesis of Vascular Contributions to Cognitive Impairment and Dementia (VCID)R01NS116058 · NINDS · UNIVERSITY OF KENTUCKY · PI DESPA, FLORIN · 2020 to 2024
$3.8M
Targeting Metabo-Redox Network Vulnerability in Heart Failure and Sudden DeathR01HL134821 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI FOSTER, D BRIAN, O'ROURKE, BRIAN · 2018 to 2021
$2.1M
Molecular Determinants of Mitochondrial Instability and ArrhythmiasR01HL137259 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI AKAR, FADI GABRIEL, O'ROURKE, BRIAN · 2017 to 2020
$2.0M
Role of myocyte Na+ dysregulation in diabetic heart diseaseR01HL135000 · NHLBI · UNIVERSITY OF KENTUCKY · PI DESPA, SANDA · 2017 to 2020
$1.7M
Mechanisms of cardiac remodeling triggered by gestational diabetesR01HL148443 · NHLBI · UNIVERSITY OF KENTUCKY · PI DESPA, SANDA · 2020 to 2023
$1.7M
Hyperamylinemia in Diabetic Heart Disease: Mechanisms, Responses, and PreventionR01HL118474 · NHLBI · UNIVERSITY OF KENTUCKY · PI DESPA, FLORIN · 2013 to 2016
$1.5M
NHLBI NIH HHS R01 HL118474NHLBI NIH HHS R01 HL134821NHLBI NIH HHS R01 HL135000NHLBI NIH HHS R01 HL137259NHLBI NIH HHS R01 HL148443NINDS NIH HHS R01 NS116058
6 · The paper itself

Abstract

Background Mitochondrial dysfunction contributes to the cardiac remodeling triggered by type 2 diabetes (T2D). Mitochondrial Ca

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2AnimalsArrhythmias, CardiacCalciumCalcium SignalingHumansMitochondriaMyocytes, CardiacRatsSarcoplasmic ReticulumSodium-Calcium ExchangerCalciumSodium-Calcium Exchangerheartmitochondrial Ca2+ uniportermitochondrial Na+/Ca2+ exchangertype 2 diabetesventricular arrhythmias

Identifiers

PMID37421267
PMCPMC10382117
OpenAlexW4383620639

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.