Evidence map›Paper›PMID 37421264›Full record

ArticleJournal of the American Heart Association2023

Trigger-Associated Clinical Implications and Outcomes in Takotsubo Syndrome: Results From the Multicenter GEIST Registry.

Toni Pätz, Francesco Santoro, Rosa Cetera, Ilaria Ragnatela, Ibrahim El-Battrawy, Matthias Mezger, Elias Rawish, Mireia Andrés-Villarreal, Manuel Almendro-Delia, Manuel Martinez-Sellés and 16 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. New insights into takotsubo syndrome: results from a multicenter cohort.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
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  7. Observational
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  11. Review
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  14. The effect of national stress events on the incidence of Takotsubo syndrome.International journal of cardiology. Heart & vasculature · 2025
    Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 16 institutions in 4 countries.

Toni PätzMedical Clinic II University Heart Center Lübeck Lübeck Germany.ORCID 0000-0002-4572-5238
Francesco SantoroDepartment of Medical and Surgery Sciences University of Foggia Italy.ORCID 0000-0001-9909-6513
Rosa CeteraDepartment of Medical and Surgery Sciences University of Foggia Italy.
Ilaria RagnatelaDepartment of Medical and Surgery Sciences University of Foggia Italy.ORCID 0000-0001-9417-5909
Ibrahim El-BattrawyDepartment of Cardiology and Angiology Bergmannsheil University Hospitals, Ruhr University of Bochum Bochum Germany.ORCID 0000-0002-0139-1045
Matthias MezgerMedical Clinic II University Heart Center Lübeck Lübeck Germany.ORCID 0000-0002-9895-590X
Elias RawishMedical Clinic II University Heart Center Lübeck Lübeck Germany.
Mireia Andrés-VillarrealServicio de Cardiología Hospital Universitario Vall d'Hebron Barcelona Spain.ORCID 0000-0002-0657-5855
Manuel Almendro-DeliaServicio de Cardiología, Hospital Virgen Macarena Sevilla Spain.ORCID 0000-0001-7144-4782
Manuel Martinez-SellésCardiology Department Hospital General Universitario Gregorio Marañon, CIBERCV. Universidad Europea, Universidad Complutense Madrid Spain.ORCID 0000-0003-0289-6229
Aitor UribarriServicio de Cardiología Hospital Universitario Vall d'Hebron Barcelona Spain.ORCID 0000-0002-6911-7480
Alberto Pérez-CastellanosServicio de Cardiología Hospital Universitario Son Espases Palma Spain.ORCID 0000-0002-5879-0012
Federico GuerraCardiology and Arrhythmology Clinic Marche Polytechnic University, University Hospital "Umberto I - Lancisi - Salesi" Ancona Italy.
Giuseppina NovoDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Cardiology Unit University of Palermo, University Hospital P. Giaccone Palermo Italy.ORCID 0000-0003-2127-7351
Enrica MarianoDepartment of Cardiology Tor Vergata University Italy.
Maria Beatrice MusumeciCardiology Department, Clinical and Molecular Medicine Department, Faculty of Medicine and Psychology Sapienza University of Rome Rome Italy.ORCID 0000-0003-4872-7981
Luca ArcariInstitute of Cardiology, Madre Giuseppina Vannini Hospital Rome Italy.ORCID 0000-0003-1410-6845
Luca CacciottiInstitute of Cardiology, Madre Giuseppina Vannini Hospital Rome Italy.
Roberta MontisciClinical Cardiology, Department of Medical Science and Public Health University of Cagliari Cagliari Italy.ORCID 0000-0002-7218-6751
Ibrahim AkinUniversity of Mannheim, DZHK Partner Site Heidelberg/Mannheim, ECAS (European Center of Angioscience) Mannheim Germany.ORCID 0000-0003-1974-6147
Holger ThieleDepartment of Internal Medicine/Cardiology Heart Center Leipzig at University of Leipzig and Leipzig Heart Institute Leipzig Germany.ORCID 0000-0002-0169-998X
Natale Daniele BrunettiDepartment of Medical and Surgery Sciences University of Foggia Italy.ORCID 0000-0001-9610-7408
Oscar VediaInstituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Hospital Clínico San Carlos, Universidad Complutense de Madrid Madrid Spain.ORCID 0000-0001-5062-3335
Ivan J Núñez-GilInstituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Hospital Clínico San Carlos, Universidad Complutense de Madrid Madrid Spain.ORCID 0000-0002-1779-3102
Ingo EitelMedical Clinic II University Heart Center Lübeck Lübeck Germany.ORCID 0000-0002-6442-246X
Thomas StiermaierMedical Clinic II University Heart Center Lübeck Lübeck Germany.ORCID 0000-0003-1957-3741
University of Foggia · ITGerman Centre for Cardiovascular Research · DENini Hospital · LBUniversidad Complutense de Madrid · ESUniversity of Lübeck · DEUniversity of Mannheim · DEVall d'Hebron Hospital Universitari · ESHospital General Universitario Gregorio Marañón · ESHospital Universitario Son Espases · ESHospital Universitario Virgen Macarena · ESLeipzig Heart Institute · DEMarche Polytechnic University · ITSapienza University of Rome · ITUniversity of Cagliari · ITUniversity of Palermo · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Takotsubo syndrome is usually triggered by a stressful event. The type of trigger seems to influence the outcome and should therefore be considered separately. Methods and Results Patients included in the GEIST (German-Italian-Spanish Takotsubo) registry were categorized according to physical trigger (PT), emotional trigger (ET), and no trigger (NT) of Takotsubo syndrome. Clinical characteristics as well as outcome predictors were analyzed. Overall, 2482 patients were included. ET was detected in 910 patients (36.7%), PT in 885 patients (34.4%), and NT was observed in 717 patients (28.9%). Compared with patients with PT or NT, patients with ET were younger, less frequently men, and had a lower prevalence of comorbidities. Adverse in-hospital events (NT: 18.8% versus PT: 27.1% versus ET: 12.1%,

Indexed as

NeoplasmsNervous System DiseasesTakotsubo CardiomyopathyAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsChest PainHumansMaleRegistriesAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor Antagonistsbroken heart syndromeoutcomestress‐induced cardiomyopathytakotsubo syndrome

Identifiers

PMID37421264
PMCPMC10382102
OpenAlexW4383621723

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.