ArticleCancer control : journal of the Moffitt Cancer Center
Diagnostic Value of Inflammation-Related Indicators in Distinguishing Early Colon Cancer and Adenomatous Polyps.
Article in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 12 citations in OpenAlex.
- A clinicopathological and hematological biomarker-based nomogram for overall survival in early-onset colorectal cancer: development, external validation, and translational implications.Translational cancer research · 2026Article
- Study on the diagnostic value of lipid and systemic inflammatory markers in colorectal adenomatous polyps and the construction of a diagnostic model.BMC gastroenterology · 2026Article
- The predictive value of complete blood count and the systemic immune-inflammation index (SII) for diagnosing malignancy in patients undergoing colonoscopy.BMC primary care · 2026Article
- A Cohort Study on Systemic Immune-Inflammation Index and Its Longitudinal Change in Relation to Colorectal Adenoma Recurrence.Journal of inflammation research · 2026Article
- A screening model for advanced colorectal neoplasia based on tumor markers and inflammatory indices: a retrospective study with an online risk calculator.Frontiers in oncology · 2026Article
- HDL-C presents a suggestive negative moderating trend for the association between total cholesterol and colorectal polyps: model construction and bootstrap internal assessment of a predictive nomogram.Frontiers in endocrinology · 2026Article
- The diagnostic value of serum cysteine protease inhibitor (CST4) in colorectal cancer: a preliminary study.BMC gastroenterology · 2025Article
- Risk factors and clinical prediction models for short-term recurrence after endoscopic surgery in patients with colorectal polyps.World journal of gastrointestinal surgery · 2025Article
- Are Calculated Immune Markers with or Without Comorbidities Good Predictors of Colorectal Cancer Survival? The Results of a Longitudinal Study.Medical sciences (Basel, Switzerland) · 2025Observational
- Diagnostic Value of the Combined Detection of Microbiota, Multiple Inflammation-Related Indicators, Serum Lipid Indices, and Tumour Markers in Colorectal Polyps: A Case-Control Study.International journal of medical sciences · 2025Article
- Applying Neural Networks to Analyse Inflammatory, Sociodemographic, and Psychological Factors in Non-Melanoma Skin Cancer and Colon Cancer: A Statistical and Artificial Intelligence Approach.Diagnostics (Basel, Switzerland) · 2024Article
- New Approaches Based on Inflammatory Indexes in the Evaluation of the Neoplastic Potential of Colon Polyps.Life (Basel, Switzerland) · 2024Article
- The association between systemic immune-inflammation index and cardiotoxicity related to 5-Fluorouracil in colorectal cancer.BMC cancer · 2024Article
- Inverted U-shaped association between the systemic immune-inflammation index and colorectal polyps in Chinese patients: a cross-sectional study.Frontiers in medicine · 2024Article
- Mediation role of body mass index in the relationship between food-specific serum immunoglobulin G reactivity and colorectal adenomas in a Chinese population: a cross-sectional study.Therapeutic advances in gastroenterology · 2024Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are few clinical symptoms in early colorectal cancer, so it is necessary to find a simple and economical tumor detection index for auxiliary diagnosis. This study aims to explore the diagnostic value of preoperative inflammation-related indicators, such as neutrophil, lymphocyte, platelet count, platelet to lymphocyte ratio (PLA), neutrophil to lymphocyte ratio (NLR), and systemic immune-inflammation index (SII), for early colorectal cancer, and determine whether inflammation-related indicators can provide more accurate diagnostic judgment for patients.
methodsThis study was a retrospective study. Patients who were first diagnosed with colorectal cancer or colorectal adenomatous polyp at Beijing Friendship Hospital from October 2016 to October 2017 were retrospectively collected. According to inclusion and exclusion criteria, a total of 342 patients were included, including 216 patients with colorectal cancer and 126 patients with colorectal adenomatous polyp. Fasting venous blood and other clinical features were collected to compare the differences between colorectal cancer and colorectal adenoma.
resultsThere were statistically significant differences in age, carcinoembryonic antigen, albumin, hemoglobin, mean platelet volume, lymphocyte, monocyte, NLR, PLA, SII, and mean platelet volume to platelet count ratio between colorectal cancer group and colorectal adenoma group (
conclusionInflammation-related indicators, such as lymphocyte, monocyte, and mean platelet volume, may serve as potential indicators to assist in the diagnosis of early colorectal cancer.
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