Evidence map›Paper›PMID 37421136›Full record

ArticleEuropean stroke journal2023

Physical and brain frailty in ischaemic stroke or TIA: Shared occurrence and outcomes. A cohort study.

Martin Taylor-Rowan, Melanie Hafdi, Bogna Drozdowska, Emma Elliott, Joanna Wardlaw, Terence J Quinn

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European stroke journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
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  6. Frailty and stroke: Global implications for assessment, research, and clinical care-A WSO scientific statement.International journal of stroke : official journal of the International Stroke Society · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Martin Taylor-RowanInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.ORCID 0000-0002-3027-5369
Melanie HafdiDepartment of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Bogna DrozdowskaInstitute of Cardiovascular and Metabolic Sciences, University of Glasgow, Glasgow, UK.ORCID 0000-0001-5705-7815
Emma ElliottInstitute of Cardiovascular and Metabolic Sciences, University of Glasgow, Glasgow, UK.
Joanna WardlawCentre for Clinical Brain Sciences, Edinburgh Center in the UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-9812-6642
Terence J QuinnInstitute of Cardiovascular and Metabolic Sciences, University of Glasgow, Glasgow, UK.ORCID 0000-0003-1401-0181
University of Glasgow · GBAmsterdam Neuroscience · NLUK Dementia Research Institute · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is increasing interest in the concept of frailty in stroke, including both physical frailty and imaging-evidence of brain frailty. We aimed to establish the prevalence of brain frailty in stroke survivors as well as the concurrent and predictive validity of various frailty measures against long-term cognitive outcomes.

methodsWe included consecutively admitted stroke or transient ischaemic attack (TIA) survivors from participating stroke centres. Baseline CT scans were used to generate an overall brain frailty score for each participant. We measured frailty via the Rockwood frailty index, and a Fried frailty screening tool. Presence of major or minor neurocognitive disorder at 18-months following stroke or TIA was established via a multicomponent assessment. Prevalence of brain frailty was established based upon observed percentages within groups defined by frailty status (robust, pre-frail, frail). We assessed the concurrent validity of brain frailty and frailty scales via Spearman's rank correlation. We conducted multivariable logistic regression analyses, controlling for age, sex, baseline education and stroke severity, to evaluate association between each frailty measure and 18-month cognitive impairment.

resultsThree-hundred-forty-one stroke survivors participated. Three-quarters of people who were frail had moderate-severe brain frailty and prevalence increased according to frailty status. Brain frailty was weakly correlated with Rockwood frailty (Rho: 0.336;

conclusionsThere appears to be value in the assessment of both physical and brain frailty in patients with ischaemic stroke and TIA. Both are associated with adverse cognitive outcomes and physical frailty remains important when assessing cognitive outcomes.

Indexed as

Brain IschemiaFrailtyIschemic Attack, TransientIschemic StrokeStrokeBrainCohort StudiesHumanscognitiondementiaFrailtystroke

Identifiers

PMID37421136
PMCPMC10683729
OpenAlexW4383506081

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.