Evidence map›Paper›PMID 37421123›Full record

ArticleMicromachines2023

Efficient Synthesis of a Schiff Base Copper(II) Complex Using a Microfluidic Device.

Masashi Kobayashi, Takashiro Akitsu, Masahiro Furuya, Tetsushi Sekiguchi, Shuichi Shoji, Takashi Tanii, Daiki Tanaka

Abstract read
In one paragraph

Article in Micromachines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Crystal structure and Hirshfeld surface analysis of aqua-(1Acta crystallographica. Section E, Crystallographic communications · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Masashi KobayashiFaculty of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan.
Takashiro AkitsuDepartment of Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.ORCID 0000-0003-4410-4912
Masahiro FuruyaCooperative Major in Nuclear Energy, Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1, Okubo, Shinjuku-ku, Tokyo 169-8555, Japan.ORCID 0000-0002-1221-2874
Tetsushi SekiguchiResearch Organization for Nano & Life Innovation, Waseda University, 513 Tsurumakicho, Shinjuku-ku, Tokyo 162-0041, Japan.
Shuichi ShojiFaculty of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan.
Takashi TaniiFaculty of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan.
Daiki TanakaResearch Organization for Nano & Life Innovation, Waseda University, 513 Tsurumakicho, Shinjuku-ku, Tokyo 162-0041, Japan.ORCID 0000-0003-1900-4848

Funding

Japan Science and Technology Agency JPMJAX21KAMinistry of Education, Culture, Sports, Science and Technology 20H00336
6 · The paper itself

Abstract

The efficient synthesis of amino acid Schiff base copper(II) complexes using a microfluidic device was successfully achieved. Schiff bases and their complexes are remarkable compounds due to their high biological activity and catalytic function. Conventionally, products are synthesized under reaction conditions of 40 °C for 4 h using a beaker-based method. However, in this paper, we propose using a microfluidic channel to enable quasi-instantaneous synthesis at room temperature (23 °C). The products were characterized using UV-Vis, FT-IR, and MS spectroscopy. The efficient generation of compounds using microfluidic channels has the potential to significantly contribute to the efficiency of drug discovery and material development due to high reactivity.

Indexed as

copper complexhigh throughputmicrofluidicSchiff base

Identifiers

PMID37421123
PMCPMC10142776

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.