Evidence map›Paper›PMID 37420565›Full record

ArticleSensors (Basel, Switzerland)2023

Shaking Device for Homogeneous Dispersion of Magnetic Beads in Droplet Microfluidics.

Maria Poles, Alessio Meggiolaro, Sebastian Cremaschini, Filippo Marinello, Daniele Filippi, Matteo Pierno, Giampaolo Mistura, Davide Ferraro

Abstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria PolesDepartment of Physics and Astronomy, University of Padua, Via Marzolo 8, 35131 Padua, Italy.
Alessio MeggiolaroDepartment of Physics and Astronomy, University of Padua, Via Marzolo 8, 35131 Padua, Italy.ORCID 0000-0002-2844-0767
Sebastian CremaschiniDepartment of Physics and Astronomy, University of Padua, Via Marzolo 8, 35131 Padua, Italy.ORCID 0000-0002-6416-5782
Filippo MarinelloDepartment of Physics and Astronomy, University of Padua, Via Marzolo 8, 35131 Padua, Italy.
Daniele FilippiDepartment of Physics and Astronomy, University of Padua, Via Marzolo 8, 35131 Padua, Italy.ORCID 0000-0001-9140-1528
Matteo PiernoDepartment of Physics and Astronomy, University of Padua, Via Marzolo 8, 35131 Padua, Italy.ORCID 0000-0002-8973-0338
Giampaolo MisturaDepartment of Physics and Astronomy, University of Padua, Via Marzolo 8, 35131 Padua, Italy.ORCID 0000-0002-3426-5475
Davide FerraroDepartment of Physics and Astronomy, University of Padua, Via Marzolo 8, 35131 Padua, Italy.ORCID 0000-0002-6760-7988

Funding

University of Padua BIRD 2021 - BiodivseqUniversity of Padua STARS grant 2019
6 · The paper itself

Abstract

Magnetic beads (or particles) having a size between 1 and 5 µm are largely used in many biochemical assays devoted to both purification and quantification of cells, nucleic acids, or proteins. Unfortunately, the use of these beads within microfluidic devices suffers from natural precipitation because of their size and density. The strategies applied thus far to cells or polymeric particles cannot be extended to magnetic beads, mainly due to their magnetization and their higher densities. We report an effective shaking device capable of preventing the sedimentation of beads that are stored in a custom PCR tube. After the characterization of the operating principle, the device is validated for magnetic beads in droplets, leading to an equal distribution between the droplets, barely affecting their generation.

Indexed as

Microfluidic Analytical TechniquesNucleic AcidsLab-On-A-Chip DevicesMagnetic FieldsMicrofluidicsNucleic Acidsdroplet microfluidicsmagnetic beadsmechanical shakingmicrofluidicspurification assayssedimentation

Identifiers

PMID37420565
PMCPMC10304097

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.