Evidence map›Paper›PMID 37420270›Full record

ArticleOrphanet journal of rare diseases2023

Treatment of relapsing multiple sclerosis in Hungary - consensus recommendation from the Hungarian neuroimmunology society.

Cecilia Rajda, Csilla Rózsa, Andrea Mike, Gábor Lovas, Zsolt Mezei, Gábor Jakab, Péter Ács, Gábor Rum, Magdolna Simó, Zita Jobbágy and 7 more

Abstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in Orphanet journal of rare diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Cecilia RajdaDepartment of Neurology, Albert Szent-Györgyi Health Centre, University of Szeged, Semmelweis u.6, Szeged, 6725, Hungary. rajda.cecilia@med.u-szeged.hu.ORCID 0000-0002-0252-4778
Csilla RózsaDepartment of Neurology, Jahn Ferenc Teaching Hospital, Köves u. 1, Budapest, 1204, Hungary.
Andrea MikeDepartment of Neurology, Szent Borbála Hospital, Dózsa György u. 77, Tatabánya, 2800, Hungary.
Gábor LovasDepartment of Neurology, Jahn Ferenc Teaching Hospital, Köves u. 1, Budapest, 1204, Hungary.
Zsolt MezeiDepartment of Neurology, Faculty of Medicine, Semmelweis University, Balassa u. 6, Budapest, 1083, Hungary.
Gábor JakabDepartment of Neurology, Uzsoki Hospital, Uzsoki u. 29-41, Budapest, 1145, Hungary.
Péter ÁcsDepartment of Neurology, Medical School, University of Pécs, Rét u. 2, Pécs, 7623, Hungary.
Gábor RumPetz Aladár Department of Neurology, County Teaching Hospital, Vasvári Pál u. 2-4, Győr, 9024, Hungary.
Magdolna SimóDepartment of Neurology, Faculty of Medicine, Semmelweis University, Balassa u. 6, Budapest, 1083, Hungary.
Zita JobbágyDepartment of Neurology, Bács-Kiskun County Teaching Hospital, Kecskemét, Nyíri u. 38, Kecskemét, 6000, Hungary.
Zita BíróDepartment of Neurology, Flór Ferenc Hospital, Semmelweis tér 1, Kistarcsa, 2143, Hungary.
Anita TrauningerDepartment of Neurology, Medical School, University of Pécs, Rét u. 2, Pécs, 7623, Hungary.
Piroska ImreDepartment of Neurology, Csolnoky Ferenc Hospital, Kórház u. 1, Veszprém, 8200, Hungary.
Klotild MátyásDepartment of Neurology, Markhot Ferenc Teaching Hospital, Knézich K. u. 1, Eger, 3300, Hungary.
István DemeDepartment of Neurology, Kaposi Mór Teaching Hospital, Tallián Gyula u 20-32, Kaposvár, 7400, Hungary.
Zsolt IllésDepartment of Neurology, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Winslows vej 4, Odense, 5000, Denmark.
Tunde CsepanyDepartment of Neurology, Faculty of Medicine, University of Debrecen, Móricz Zs. Krt. 22, Debrecen, 4032, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) may impact quality of life, careers and family plans of the affected individuals. The current treatments with disease modifying therapies aim to prevent people with MS (pwMS) from disability accumulation and progression. Different countries have different reimbursement policies resulting in inequalities in patient care among geographical regions. Access to anti-CD20 therapies for relapsing MS is restricted in Hungary because therapy of individual cases only is reimbursed. In the light of the latest research and national guidelines, 17 Hungarian MS experts agreed on 8 recommendations regarding relapsing pwMS using the Delphi round method. Strong agreement (> 80%) was achieved in all except one recommendation after three rounds, which generated a fourth Delphi round. The experts agreed on treatment initiation, switch, follow-up and discontinuation, as well as on special issues such as pregnancy, lactation, elderly population, and vaccination. Well-defined national consensus protocols may facilitate dialogue between policymakers and healthcare professionals and thus contribute to better patient care in the long run.

Indexed as

Multiple SclerosisAgedFemaleHumansHungaryPregnancyQuality of LifeConsensusMultiple sclerosisRecommendationTreatment

Identifiers

PMID37420270
PMCPMC10329288

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.