ArticleBMC oral health2023
Association between periodontal disease status and risk of atrial fibrillation: a nationwide population-based cohort study.
Article in BMC oral health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Association of periodontal disease with risk atrial fibrillation: systematic review.BMC oral health · 2025Pooled it
- Anti-Porphyromonas gingivalis Antibody Levels in Patients With Stroke and Atrial Fibrillation: A Systematic Review and Meta-Analysis.Clinical and experimental dental research · 2024Pooled it
- From Periodontal Inflammation to Atrial Fibrillation: Molecular Links Through Thrombospondin-1, Galectin-3, and SGLT2-Related Pathways.International journal of molecular sciences · 2026Review
- Increased cardiovascular disease risk in patients with periodontal disease: Insights from studies of periodontal treatment.American heart journal plus : cardiology research and practice · 2026Review
- The Interplay Between Periodontitis and Atrial Fibrillation: Inflammation as a Common Pathophysiological Bridge.International journal of molecular sciences · 2026Review
- Review
- Denture hygiene knowledge, cleaning practices, and denture stomatitis among primary care patients in Alkharj, Saudi Arabia: compliance predictors, barriers and educational preferences: a cross-sectional study.Frontiers in medicine · 2026Article
- Relationship between periodontitis and atrial fibrillation recurrence after ablation: a systematic review.Frontiers in cardiovascular medicine · 2026Review
- The role of periodontitis as a modifier of diabetes mellitus in older patients with atrial fibrillation.BMC endocrine disorders · 2025Observational
- A Review on the Role of Oral Bacteria in Stroke.International journal of molecular sciences · 2025Review
- Investigating the link between oral health conditions and systemic diseases: A cross-sectional analysis.Scientific reports · 2025Article
- Association between regular dental scaling and stroke risk in patients with periodontal diseases: evidence from a Korean nationwide database.Epidemiology and health · 2025Article
- Chronic periodontal disease is related with newly developing hypertension: a nationwide cohort study.Clinical hypertension · 2024Article
- Oral condition at admission predicts functional outcomes and hospital-acquired pneumonia development among acute ischemic stroke patients.Clinical oral investigations · 2024Article
- Genomic Medicine in Canine Periodontal Disease: A Systematic Review.Animals : an open access journal from MDPI · 2023Review
- Association of high estimated glomerular filtration rate with risk of atrial fibrillation: a nationwide cohort study.Frontiers in medicine · 2023Article
- Association of total cholesterol variability with risk of venous thromboembolism: A nationwide cohort study.PloS one · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeriodontal disease can activate an immune process linked to systemic diseases, including atrial fibrillation. However, the relationship between periodontal disease and atrial fibrillation remains unclear.
aimThis study aimed to investigate whether changes in periodontal disease status are associated with the risk of atrial fibrillation.
methodsUsing the National Health Insurance Database Korea, participants who underwent the first oral health examination in 2003 and a second examination in 2005-2006 without a history of atrial fibrillation were included. Participants were grouped according to changes in periodontal disease status during two oral examinations: periodontal disease-free, periodontal disease-recovered, periodontal disease-developed, and periodontal disease-chronic. The outcome was the incidence of atrial fibrillation.
resultsThe study included 1,254,515 participants, with a median follow-up of 14.3 years and 25,402 (2.02%) cases of atrial fibrillation occurred. During follow-up, the risk of atrial fibrillation was highest in the periodontal disease-chronic group, followed by the periodontal disease-developed, periodontal disease-recovered, and periodontal disease-free groups (p for trend < 0.001). Moreover, recovery from periodontal disease was associated with a reduced risk of atrial fibrillation compared to a chronic periodontal disease status (Hazard ratio: 0.97, 95% Confidence interval: 0.94-0.99, p = 0.045). The development of periodontal disease was associated with an increased risk of atrial fibrillation compared to being periodontal disease-free (Hazard ratio: 1.04, 95% Confidence interval: 1.01-1.08, p = 0.035).
conclusionOur findings suggest that changes in periodontal disease status impact the risk of atrial fibrillation. Management of periodontal disease may help prevent atrial fibrillation.
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