ArticleCardiovascular diabetology2023
Association between the triglyceride-glucose index and the risk of mortality among patients with chronic heart failure: results from a retrospective cohort study in China.
Article in Cardiovascular diabetology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 50 papers, 3 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Does diabetes modify the triglyceride-glucose index associated with cardiovascular events and mortality? A meta-analysis of 50 cohorts involving 7,239,790 participants.Cardiovascular diabetology · 2025Pooled it
- Triglyceride-glucose index and the prognosis of patients with heart failure: A meta-analysis.Biomolecules & biomedicine · 2025Pooled it
- A meta-analysis of the prognostic value of the TyG index in heart failure.Frontiers in endocrinology · 2025Pooled it
- Cardiometabolic index (CMI) and sarcopenia as predictors of all-cause and cardiovascular mortality in chronic kidney disease: a NHANES-based cohort study.Renal failure · 2026Article
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- The Association Between Triglyceride-Glucose Index and Mortality Risk in Cardiovascular Disease Patients: A Meta-Analysis.Journal of clinical medicine research · 2026Article
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- Development and external validation of an explainable machine learning model for in-hospital mortality risk stratification in intensive care unit patients with heart failure.Frontiers in cardiovascular medicine · 2026Article
- Prognostic significance of the TyG index combined with the NLR for heart failure: a retrospective study.Frontiers in cardiovascular medicine · 2026Article
- Prognostic value of the triglyceride-glucose Index in elderly patients with acute decompensated heart failure: a one-year mortality analysis.Frontiers in cardiovascular medicine · 2026Article
- Latent transition analysis of home-based fluid management during the vulnerable phase in patients with chronic heart failure: impact on symptom burden.Frontiers in cardiovascular medicine · 2026Article
- C-reactive protein-triglyceride-glucose index predicts acute pancreatitis severity: a retrospective cross-sectional study.Frontiers in endocrinology · 2026Article
- Prognostic significance of the C-reactive protein-triglyceride-glucose index for all-cause and cardiovascular mortality in peritoneal dialysis: a multicenter cohort study.Scientific reports · 2025Article
- The Incremental Prognostic Value of Incorporating the Triglyceride-Glucose Index into the Traditional Cardiovascular Risk Factors for the Long-term Prognosis in Ischemic Cardiomyopathy Patients with HFpEF following Coronary Artery Bypass Grafting: A Multicenter Cohort Study.Journal of atherosclerosis and thrombosis · 2025Article
- The association between triglyceride-glucose index and all-cause/cardiovascular mortality in patients with different glucose metabolism statuses.Cardiovascular diabetology · 2025Article
- Association between dynamic changes in the triglyceride-glucose index and prognosis in patients with acute ST-segment elevation myocardial infarction.Cardiovascular diabetology · 2025Article
- Non-linear associations of triglyceride glucose index with all-cause and cardiovascular mortality in patients with heart failure.Diabetology & metabolic syndrome · 2025Article
- The role of TyG index in predicting low left ventricular ejection fraction after acute coronary syndrome.Biomarkers in medicine · 2025Article
- Association of triglyceride-glucose index trajectories with the risk of worsening heart failure in elderly patients with chronic heart failure and type 2 diabetes: a competing risk analysis.Cardiovascular diabetology · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe triglyceride-glucose (TyG) index has been demonstrated to be a reliable surrogate marker of insulin resistance (IR) and an effective predictive index of cardiovascular (CV) disease risk. However, its long-term prognostic value in patients with chronic heart failure (CHF) remains uncertain.
methodsA total of 6697 consecutive patients with CHF were enrolled in this study. Patients were divided into tertiles according to their TyG index. The incidence of primary outcomes, including all-cause death and CV death, was recorded. The TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting blood glucose (mg/dL)/2].
resultsDuring a median follow-up of 3.9 years, a total of 2158 (32.2%) all-cause deaths and 1305 (19.5%) CV deaths were documented. The incidence of primary events from the lowest to the highest TyG index tertiles were 50.61, 64.64, and 92.25 per 1000 person-years for all-cause death and 29.05, 39.40, and 57.21 per 1000 person-years for CV death. The multivariate Cox hazards regression analysis revealed hazard ratios for all-cause and CV deaths of 1.84 (95% CI 1.61-2.10; P for trend < 0.001) and 1.94 (95% CI 1.63-2.30; P for trend < 0.001) when the highest and lowest TyG index tertiles were compared. In addition, the predictive ability of the TyG index against all-cause death was more prominent among patients with metabolic syndrome and those with heart failure with preserved ejection fraction phenotype (both P for interaction < 0.05). Furthermore, adding the TyG index to the established model for all-cause death improved the C‑statistic value (0.710 for the established model vs. 0.723 for the established model + TyG index, P < 0.01), the integrated discrimination improvement value (0.011, P < 0.01), the net reclassification improvement value (0.273, P < 0.01), and the clinical net benefit (probability range, 0.07-0.36).
conclusionsThe TyG index was significantly associated with the risk of mortality, suggesting that it may be a reliable and valuable predictor for risk stratification and an effective prognostic indicator in patients with CHF.
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