Evidence map›Paper›PMID 37420191›Full record

ArticleBMC geriatrics2023

The association between neuropeptide oxytocin and neuropsychiatric disorders after orthopedic surgery stress in older patients.

Wanru Dong, Zengbo Ding, Xiao Wu, Ran Wan, Ying Liu, Liubao Pei, Weili Zhu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC geriatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Wanru DongDrug Safety Evaluation Center, Heilongjiang University of Chinese Medicine, Harbin, 150040, China.
Zengbo DingNational Institute On Drug Dependence and Beijing Key Laboratory of Drug Dependence Research, Peking University, Beijing, 100191, China.
Xiao WuNational Institute On Drug Dependence and Beijing Key Laboratory of Drug Dependence Research, Peking University, Beijing, 100191, China.
Ran WanDepartment of Orthopedics, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
Ying LiuCollege of Pharmacy, Hainan Medical College, Haikou, 570100, China.
Liubao PeiDepartment of Orthopedics, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China. 007959@hrbmu.edu.cn.
Weili ZhuNational Institute On Drug Dependence and Beijing Key Laboratory of Drug Dependence Research, Peking University, Beijing, 100191, China. zhu_wl@bjmu.edu.cn.
Peking University · CNHarbin Medical University · CNHainan Medical College Hospital · CNHeilongjiang University of Chinese Medicine · CN

Funding

China National Post-doctoral Scientific Fund and Heilongjiang Provincial Post-doctoral Funding Project 2018M641887, LBH-Z18252Key Basic Research Project of Shandong Provincial Natural Science Foundation ZR2019ZD27National Natural Science Foundation of China 82271552National Nature Science Foundation of China 82004245Natural Science Foundation of Hainan Province 819MS061
6 · The paper itself

Abstract

backgroundThe health outcomes of geriatric patients exposed to surgery were found to be enhanced by social support and stress management. The aim of this study was to characterise the relationship between oxytocin and neuropsychiatric disorders after surgery.

methodsA total of 132 geriatric patients aged ≥ 60 years received orthopedic surgery in the First Affiliated Hospital of Harbin Medical University (Harbin, China) were enrolled in the present study. The salivary levels of stress hormone cortisol and oxytocin were measured by enzyme-linked immunosorbent assay for the screening of the stress state and oxytocin function. Moreover, the Depression Anxiety and Stress Scale (DASS), the Geriatric Anxiety Inventory (GAI), the Geriatric Depression Scale (GDS) and the Montgomery-Åsberg Depression Rating Scale (MADRS) were conducted to identify the severity of anxiety and depression. The association between oxytocin and mental health was performed by linear regression analyses in older patients receiving orthopedic surgery. Finally, the Duke Social Support Index (DSSI) was selected to measure the social support and the potential link to mental outcomes.

resultsThe scores from questionnaires showed that female patients with higher social support and higher levels of oxytocin demonstrated better stress-reducing responses as reflected by lower cortisol and decreased anxiety and depression symptoms. Regression analyses revealed that there was a significant association between oxytocin and scores in DASS, GAI, GDS, MADRS and DSSI, suggesting a potential link between peripheral oxytocin function and mood outcomes after orthopedic surgery.

conclusionsOur findings reveal that oxytocin enhances the stress-protective effects of social support and reduces anxiety and depression states under stressful circumstances, particularly in older women receiving orthopedic surgery.

Indexed as

Orthopedic ProceduresOxytocinAgedAnxietyDepressionFemaleHumansHydrocortisoneHydrocortisoneOxytocinAnxietyDepressionOrthopedic surgeryOxytocinPostoperative recoverySocial supportStress response

Identifiers

PMID37420191
PMCPMC10329356
OpenAlexW4383499332

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.