Evidence map›Paper›PMID 37419973›Full record

SynthesisWorld journal of urology2023

Performance of indocyanine green in sentinel lymph node mapping and lymph node metastasis in penile cancer: systematic review, meta-analysis, and single-center experience.

Rui Zhang, Yaqin Zhang, Sihan Dong, Kai Pang, Xiaofeng Yang, Xunbin Wei

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in World journal of urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rui ZhangInstitute of Medical Technology, Peking University Health Science Center, Beijing, 100080, China.
Yaqin ZhangFirst Clinical Medical College, Nanjing Medical University, Nanjing, 210000, China.
Sihan DongInstitute of Medical Technology, Peking University Health Science Center, Beijing, 100080, China.
Kai PangInstrument Science and Opto-Electronics Engineering, Beijing Information Science and Technology University, Beijing, 100192, China.
Xiaofeng YangDepartment of Urology, First Hospital of Shanxi Medical University, Taiyuan, 030001, China.
Xunbin WeiInstitute of Medical Technology, Peking University Health Science Center, Beijing, 100080, China. xwei@bjmu.edu.cn.

Funding

Central Guidance on Local Science and Technology Development Fund of Shanxi Province YDZJSX2021C010Special Fund for Research on National Major Research Instruments of China 62027824
6 · The paper itself

Abstract

purposeThe aim of this study was to investigate the overall sensitivity and specificity of indocyanine green (ICG)-near-infrared (NIR) fluorescence imaging in the detection of sentinel lymph node metastasis (SLNM) in penile cancer.

methodsWe searched PubMed, Embase, Web of Science, Scopus, and the Cochrane Library databases to identify manuscripts where ICG was intravenously administered prior to or during penile cancer surgery, with no restriction on language or publication status. The results extracted are presented as forest plots.

resultsSeven studies were included in the analysis. The median sensitivity and specificity of ICG-NIR imaging for SLNM detection were 100 and 4%, respectively; the pooled sensitivity was 100.0% (95% confidence interval [CI] 97.0-100.0) and specificity was 2.0% (95% CI 1.0-3.0). There was no significant difference in the diagnostic results between different injection sites and doses in each experimental group.

conclusionTo our knowledge, this meta-analysis is the first to summarize the diagnostic performance of ICG-NIR imaging for SLNM detection in penile cancer. ICG is sensitive in the imaging of SLN tissue, which can consequently improve the accuracy of lymph node detection. However, the specificity is very low.

Indexed as

LymphadenopathyPenile NeoplasmsSentinel Lymph NodeColoring AgentsHumansIndocyanine GreenLymphatic MetastasisLymph NodesMaleOptical ImagingSentinel Lymph Node BiopsyColoring AgentsIndocyanine GreenIndocyanine greenPenile cancerSensitivitySentinel lymph nodeSpecificity

Identifiers

PMID37419973

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.