Evidence map›Paper›PMID 37419958›Full record

ArticleEye (London, England)2024

The Infectious Uveitis Treatment Algorithm Network (TITAN) Report 2-global current practice patterns for the management of Cytomegalovirus anterior uveitis.

Zheng Xian Thng, Ikhwanuliman Putera, Ilaria Testi, Kevin Chan, Mark Westcott, Soon-Phaik Chee, Andrew D Dick, John H Kempen, Bahram Bodaghi, Jennifer E Thorne and 18 more

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Eye (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Topical versus oral antiviral therapy for cytomegalovirus anterior uveitis: a multicenter study in Taiwan.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 20 institutions in 11 countries.

Zheng Xian Thng *National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore.ORCID 0000-0003-3275-7537
Ikhwanuliman Putera *Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Kirana Eye Hospital, Jakarta, Indonesia.ORCID 0000-0002-9350-5133
Ilaria TestiNational Institute for Health Research Biomedical Research Centre, Moorfields Eye Hospital, London, UK.
Kevin ChanLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Mark WestcottNational Institute for Health Research Biomedical Research Centre, Moorfields Eye Hospital, London, UK.
Soon-Phaik CheeSingapore National Eye Centre, Singapore, Singapore.
Andrew D DickNational Institute for Health Research Biomedical Research Centre, Moorfields Eye Hospital, London, UK.
John H KempenDepartment of Ophthalmology, Massachusetts Eye and Ear/Harvard Medical School; and Schepens Eye Research Institute, Boston, MA, USA.ORCID 0000-0002-2967-4792
Bahram BodaghiDept of Ophthalmology, IHU FOReSIGHT, Sorbonne-APHP, 47-83 bd de l'Hopital, 75013, Paris, France.
Jennifer E ThorneWilmer Eye Institute, Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Talin Barisani-AsenbauerInstitute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Marc D de SmetDept of Ophthalmology, Leiden University, Leiden, Netherlands.
Justine R SmithFlinders University College of Medicine & Public Health, Adelaide, Australia and Queensland Eye Institute, Brisbane, QLD, Australia.
Peter McCluskeyDepartment of Ophthalmology, Director Save Sight Institute, The University of Sydney, Sydney, NSW, Australia.
Rina La Distia NoraDepartment of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Kirana Eye Hospital, Jakarta, Indonesia.
Douglas A JabsWilmer Eye Institute, Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Joke H de BoerDepartment of Ophthalmology, Utrecht University Medical Center, Utrecht, The Netherlands.
H Nida SenNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Debra A GoldsteinNorthwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Moncef KhairallahDepartment of Ophthalmology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Janet L DavisBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID 0000-0001-6395-5881
James T RosenbaumOregon Health and Science University, Portland, OR, USA.
Nicholas P JonesSchool of Biological Sciences, University of Manchester, Manchester, UK.
Quan Dong NguyenByers Eye Institute, Stanford Medical School, Palo Alto, CA, USA.
Carlos PavesioNational Institute for Health Research Biomedical Research Centre, Moorfields Eye Hospital, London, UK.
Rupesh AgrawalNational Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore. rupesh_agrawal@ttsh.com.sg.
Vishali GuptaAdvanced Eye Centre, Post-graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. vishalisara@yahoo.co.in.
TITAN consensus guidelines group
National Institute for Health Research · GBErasmus MC · NLNanyang Technological University · SGNational Institutes of Health · USFlinders University · AULegacy Health · USLeiden University · NLNational University of Singapore · SGNorthwestern University · USPost Graduate Institute of Medical Education and Research · INUniversity of Manchester · GBDélégation Paris 5 · FRHospital Fatuma Bourguiba Monastir · TNJohns Hopkins University · USMassachusetts Eye and Ear Infirmary · USSmith-Kettlewell Eye Research Institute · USTan Tock Seng Hospital · SGThe University of Sydney · AUUniversity of Miami · USUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo present current practice patterns in the diagnosis and management of Cytomegalovirus anterior uveitis (CMV AU) by uveitis experts worldwide.

methodsA two-round modified Delphi survey with masking of the study team was performed. Based on experience and expertise, 100 international uveitis specialists from 21 countries were invited to participate in the survey. Variation in the diagnostic approaches and preferred management of CMV AU was captured using an online survey platform.

resultsSeventy-five experts completed both surveys. Fifty-five of the 75 experts (73.3%) would always perform diagnostic aqueous tap in suspected CMV AU cases. Consensus was achieved for starting topical antiviral treatment (85% of experts). About half of the experts (48%) would only commence systemic antiviral treatment for severe, prolonged, or atypical presentation. The preferred specific route was ganciclovir gel 0.15% for topical treatment (selected by 70% of experts) and oral valganciclovir for systemic treatment (78% of experts). The majority of experts (77%) would commence treatment with topical corticosteroid four times daily for one to two weeks along with antiviral coverage, with subsequent adjustment depending on the clinical response. Prednisolone acetate 1% was the drug of choice (opted by 70% of experts). Long-term maintenance treatment (up to 12 months) can be considered for chronic course of inflammation (88% of experts) and those with at least 2 episodes of CMV AU within a year (75-88% of experts).

conclusionsPreferred management practices for CMV AU vary widely. Further research is necessary to refine diagnosis and management and provide higher-level evidence.

Indexed as

Cytomegalovirus InfectionsUveitis, AnteriorAntiviral AgentsAqueous HumorCytomegalovirusGanciclovirHumansAntiviral AgentsGanciclovir

Identifiers

PMID37419958
PMCPMC10764804
OpenAlexW4383532362

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.