ArticleMayo Clinic proceedings2023
The Association Between Thyroid Stimulating Hormone and Depression: A Historical Cohort Study.
Article in Mayo Clinic proceedings, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Could thyrotropin serum level characterize major depressive disorder phenotype? A systematic review and meta-analysis.Journal of endocrinological investigation · 2026Pooled it
- Catatonia treatments and risk of recurrence.Journal of affective disorders · 2026Article
- Mediation effects of thyroid hormones in the associations between essential metal elements and anxiety or depression symptoms in the elderly.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Association of SGLT2 inhibitors with suicidality, all-cause mortality, and hospitalization in bipolar disorder: A cohort study of 1.23 million adults.Journal of affective disorders · 2026Article
- Thyroid Dysfunction and the Risk of Clinically Relevant Depression: A Longitudinal Cohort Study.Mayo Clinic proceedings · 2026Article
- Hepatic Safety of Ketamine and Esketamine for Treatment-Resistant Depression: A Real-World Cohort Study.Journal of clinical psychopharmacology · 2026Article
- Thyroid dysfunction and Research Domain Criteria framework-based depression phenotypes: Insights from a historical longitudinal cohort.Journal of affective disorders · 2026Article
- Postmarketing pharmacovigilance study of levothyroxine based on FDA adverse event reporting system (FAERS) and Mendelian randomization.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- SGLT2 Inhibitors Associated With Improved Kidney Function in Lithium-Treated Patients With Mood Disorders: A Real-World Historical Cohort Study.Bipolar disorders · 2026Article
- Prevalence of thyroid dysfunction in psychiatric inpatients: A cross sectional prevalence study.Bioinformation · 2026Article
- Sodium-glucose cotransporter-2 inhibitors lower risk of kidney replacement therapy and mortality in bipolar disorder with chronic kidney disease.Therapeutic advances in psychopharmacology · 2026Article
- Unraveling the Genetic Link Between Endocrine Hormones and Psychiatric Disorders: An Atlas of Genetic Correlations.Endocrines · 2025Article
- Long-Term Outcomes in Patients With Treatment-Refractory Depression Receiving Intravenous Ketamine and Intranasal Esketamine: An Observational Study.The Journal of clinical psychiatry · 2025Observational
- The Association Between Thyrotropin and Clinically Relevant Depression: A Retrospective Cross-Sectional Study.Thyroid : official journal of the American Thyroid Association · 2025Article
- Sex-modulated association between thyroid stimulating hormone and informant-perceived anxiety in non-depressed older adults: Prediction models and relevant cutoff value.Scientific reports · 2025Article
- The Quartile Levels of Thyroid-stimulating Hormone at Newborn Screening Stratified Risks of Neurodevelopmental Impairment in Extremely Preterm Infants: A Population Cohort Study.Journal of epidemiology · 2024Article
- Depression Is Associated with a Higher Risk of Mortality among Breast Cancer Survivors: Results from the National Health and Nutrition Examination Survey-National Death Index Linked Study.Brain sciences · 2024Article
- Identifying clinical predictors for considering brain FDG-PET imaging in patients with catatonia: A case-control study.Schizophrenia research · 2024Article
- Risk Factors for Post-Stroke Depression Following the Lifting of COVID-19 Restrictions.International journal of general medicine · 2024Article
- The Association between Depression, Anxiety, and Thyroid Disease: A UK Biobank Prospective Cohort Study.Depression and anxiety · 2024Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo investigate the association between thyroid-stimulating hormone (TSH) and clinically relevant depression (CRD) in a population-based study. PATIENTS AND
methodsAdult patients (≥18 years of age) who received care at Mayo Clinic in Rochester, Minnesota, and completed a TSH and Patient Health Questionnaire - 9 (PHQ-9) within 6 months of each other, between July 8, 2017, and August 31, 2021, were included. Demographics, medical comorbidities, thyroid function laboratory data, psychotropic medications, presence of primary thyroid disorder, thyroid hormone replacement (T4 and/or T3), and mood disorder diagnoses (using International Classification of Diseases, 10
resultsThe cohort included 29,034 patients, mean age 51.4 years, 65% females, 89.9% White, and a mean body mass index of 29.9 kg/m
conclusionIn this large population-based cross-sectional study, we report that low TSH was associated with higher odds of depression. Future longitudinal cohort studies are needed to investigate the relationship between thyroid dysfunction and depression as well as sex differences.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.