Evidence map›Paper›PMID 37419557›Full record

ArticleRevista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia

[Combined histiocytosis of the Langerhans group (Langerhans cell histiocytosis and Erdheim-Chester disease) in a 64-year-old man with BRAF and NRAS mutations: a case report].

María Soledad Rodríguez-Duque, Paula Martín Soler, M Carmen González Vela, Jose Javier Gómez Román

Erratum issuedAbstract readCase ReportsEnglish Abstract
PubMed Publisher
In one paragraph

Article in Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

María Soledad Rodríguez-DuqueServicio de Anatomía Patológica, Hospital Universitario Marqués de Valdecilla, Santander, España. Electronic address: marisolrd92@gmail.com.
Paula Martín SolerServicio de Anatomía Patológica, Hospital Universitario Marqués de Valdecilla, Santander, España.
M Carmen González VelaServicio de Anatomía Patológica, Hospital Universitario Marqués de Valdecilla, Santander, España.
Jose Javier Gómez RománServicio de Anatomía Patológica, Hospital Universitario Marqués de Valdecilla, Santander, España.
Marqués de Valdecilla University Hospital · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a case of a 64-year-old male with a history of Crohn's disease who presented with an episode of acute abdominal pain. He was being investigated for a dermatological lesion. A skin and lung biopsy both revealed histiocytosis of the "L" (Langerhans) group. The skin biopsy showed a proliferation of histiocytic cells expressing Langerin, CD1a and S100 and the molecular study was positive for the BRAF p.V600E mutation. In the lung biopsy, a proliferation of histiocytic cells was found, which were positive for CD68 and S100 and negative for Langerin and CD1a; mutations in NRAS c.38G>A in exon 2 (p.G13D) were also detected.

Indexed as

Erdheim-Chester DiseaseHistiocytosis, Langerhans-CellGTP PhosphohydrolasesHistiocytesHumansMaleMembrane ProteinsMiddle AgedMutationProto-Oncogene Proteins B-rafBRAF protein, humanGTP PhosphohydrolasesMembrane ProteinsNRAS protein, humanProto-Oncogene Proteins B-rafBRAFErdheim-ChesterHistiocitosisHistiocitosis grupo LHistiocytosisLangerhansL group histiocytosisMAP cinasasMAP kinasasNRAS

Identifiers

PMID37419557
OpenAlexW3204428510

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.