Evidence map›Paper›PMID 37419349›Full record

ArticleThe Science of the total environment2023

Indoor (residential) and ambient particulate matter associations with urinary oxidative stress biomarkers in a COPD cohort.

Jennifer Maccarone, Stephanie T Grady, Marilyn L Moy, Jaime E Hart, Choong-Min Kang, Brent A Coull, Joel D Schwartz, Petros Koutrakis, Junfeng Zhang, Eric Garshick

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Science of the total environment, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Jennifer MaccaroneVA Boston Healthcare System, Boston, MA, USA; The Pulmonary Center, Boston University School of Medicine, Boston, MA, USA. Electronic address: Jennifer.Maccarone@va.gov.
Stephanie T GradyBoston University School of Public Health, Boston, MA, USA.
Marilyn L MoyVA Boston Healthcare System, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Jaime E HartChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Choong-Min KangHarvard T.H. Chan School of Public Health, Boston, MA, USA.
Brent A CoullHarvard T.H. Chan School of Public Health, Boston, MA, USA.
Joel D SchwartzHarvard Medical School, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Petros KoutrakisHarvard T.H. Chan School of Public Health, Boston, MA, USA.
Junfeng ZhangNicholas School of the Environment and Duke Global Health Institute, Duke University, Durham, NC, USA.
Eric GarshickVA Boston Healthcare System, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Harvard University · USBoston University · USDuke University · USVA Boston Healthcare System · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
COPD and Response to Traffic Related ParticlesR01ES019853 · NIEHS · HARVARD MEDICAL SCHOOL · PI GARSHICK, ERIC · 2012 to 2016
$3.1M
Retrospective assessment of radon progeny and pollution effects in COPDR21ES029637 · NIEHS · HARVARD MEDICAL SCHOOL · PI GARSHICK, ERIC · 2019 to 2020
$453k
NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES019853NIEHS NIH HHS R21 ES029637
6 · The paper itself

Abstract

objectivesOxidative stress contributes to chronic obstructive pulmonary disease (COPD) pathophysiology. Associations between indoor (residential) exposure to particulate matter ≤2.5 μm in diameter (PM

methodsBetween 2012 and 2017, 140 patients with COPD completed in-home air sampling over one week intervals, followed by collection of urine samples to measure oxidative stress biomarkers, malondialdehyde (MDA), a marker of lipid peroxidation, and 8-hydroxy-2' -deoxyguanosine (8-OHdG), a marker of oxidative DNA damage. Ambient (central site) BC and PM

resultsThere were positive associations (% increase per IQR; 95 % CI) of directly measured indoor BC with total MDA (6.96; 1.54, 12.69) and 8-OHdG (4.18; -0.67, 9.27), and similar associations with both indoor BC of outdoor origin and ambient BC. There were no associations with directly measured indoor PM

conclusionsIn homes with few indoor combustion sources, directly measured indoor BC, estimates of indoor BC and PM

Indexed as

Air PollutantsAir Pollution, IndoorPulmonary Disease, Chronic Obstructive8-Hydroxy-2'-DeoxyguanosineBiomarkersHumansOxidative StressParticle SizeParticulate MatterSoot8-Hydroxy-2'-DeoxyguanosineAir PollutantsBiomarkersParticulate MatterSoot8-Hydroxy-2′-deoxyguanosineAir pollutionBlack carbonChronic obstructive pulmonary diseaseMalondialdehydePM(2.5)

Identifiers

PMID37419349
PMCPMC10529440
OpenAlexW4383199436

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.