ReviewNeuroscience and biobehavioral reviews2023
Stress to inflammation and anhedonia: Mechanistic insights from preclinical and clinical models.
Review in Neuroscience and biobehavioral reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Consummatory deficits in close social reward predict inflammation-induced depressed mood.Psychoneuroendocrinology · 2026Trial
- Inflammation-induced depressed mood and reward responsivity as a function of age in female adults: a randomized controlled trial of endotoxin.Translational psychiatry · 2025Trial
- [Paeoniflorin alleviates cancer-related fatigue during chemotherapy for breast cancer by targeting EZH2/CCNE1 to regulate cell cycle and inflammatory microenvironment].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Peripheral immune-redox signatures associate with cortical network alterations in anhedonic depression.Molecular psychiatry · 2026Article
- Neural response to reward as a potential pathway from inflammation to anhedonia in adolescents at risk for depression.Brain, behavior, & immunity - health · 2026Article
- Interplay Among Reward Processing, Schizotypal Traits, and Psychosocial Stress in a Large Chinese Young Adult Sample: A Cross-Sectional Network Analysis.PsyCh journal · 2026Article
- Insomnia longitudinally predicts reduced reward motivation in adults with elevated depressive symptoms.Journal of affective disorders · 2026Article
- Article
- Basal Ganglia Dopamine Availability and Immune Activation Interact and Relate to Anhedonia Severity among Youth with Depression.Research square · 2026Article
- Inflammatory models of depression in rodents and humans.Frontiers in psychiatry · 2026Review
- The potential of neuromelanin-sensitive MRI in psychiatric disorders.Neuroscience applied · 2026Review
- Role of Reactive Astrocytes and Microglia: Wnt/β-Catenin Signaling in Neuroprotection and Repair in Parkinson's Disease.International journal of molecular sciences · 2025Review
- Neurobiological Mechanisms and Therapeutic Potential of Glucagon-like Peptide-1 Receptor Agonists in Binge Eating Disorder: A Narrative Review.International journal of molecular sciences · 2025Review
- The motivational drives of sickness: Acute changes in self-rated motivation during experimental endotoxemia assessed with the newly developed Motivation Scale of Sickness (MOSSick).Comprehensive psychoneuroendocrinology · 2025Article
- Temporal Predictions from Anhedonia To Anxiety in Adolescents with Major Depressive Disorder.Research on child and adolescent psychopathology · 2025Article
- An approach to screen susceptible rats and efficacy of an antidepressive treatment after chronic stress.IBRO neuroscience reports · 2025Article
- Network Pharmacology-Guided Evaluation of Ginger and Cornelian Cherry Extracts Against Depression and Metabolic Dysfunction in Estrogen-Deficient Chronic Stressed Rats.International journal of molecular sciences · 2025Article
- The interface of depression and diabetes: treatment considerations.Translational psychiatry · 2025Review
- Value-based cognitive control moderates the relation of inflammation with depression in adolescents.Social cognitive and affective neuroscience · 2025Article
- Prevalence of anhedonia in women with deep endometriosis.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Anhedonia, as evidenced by impaired pleasurable response to reward, reduced reward motivation, and/or deficits in reward-related learning, is a common feature of depression. Such deficits in reward processing are also an important clinical target as a risk factor for depression onset. Unfortunately, reward-related deficits remain difficult to treat. To address this gap and inform the development of effective prevention and treatment strategies, it is critical to understand the mechanisms that drive impairments in reward function. Stress-induced inflammation is a plausible mechanism of reward deficits. The purpose of this paper is to review evidence for two components of this psychobiological pathway: 1) the effects of stress on reward function; and 2) the effects of inflammation on reward function. Within these two areas, we draw upon preclinical and clinical models, distinguish between acute and chronic effects of stress and inflammation, and address specific domains of reward dysregulation. By addressing these contextual factors, the review reveals a nuanced literature which might be targeted for additional scientific inquiry to inform the development of precise interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.