Evidence map›Paper›PMID 37419138›Full record

ArticleAIDS care2024

Alcohol and drug use severity are independently associated with antiretroviral adherence in the current treatment era.

J Ma, B Luu, S A Ruderman, B M Whitney, J O Merrill, L S Mixson, R M Nance, L N Drumright, A W Hahn, R J Fredericksen and 20 more

Open access · greenAbstract read
In one paragraph

Article in AIDS care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 10 institutions in 2 countries.

J MaDepartment of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-6849-3206
B LuuDepartment of Medicine, University of Toronto, Toronto, Canada.
S A RudermanDepartment of Medicine, University of Washington, Seattle, WA, USA.
B M WhitneyDepartment of Medicine, University of Washington, Seattle, WA, USA.
J O MerrillDepartment of Medicine, University of Washington, Seattle, WA, USA.
L S MixsonDepartment of Medicine, University of Washington, Seattle, WA, USA.
R M NanceDepartment of Medicine, University of Washington, Seattle, WA, USA.
L N DrumrightDepartment of Medicine, University of Washington, Seattle, WA, USA.
A W HahnDepartment of Medicine, University of Washington, Seattle, WA, USA.
R J FredericksenDepartment of Medicine, University of Washington, Seattle, WA, USA.
G ChanderDepartment of Medicine, University of Washington, Seattle, WA, USA.
B LauDepartment of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.
M E McCaulDepartment of Psychiatry, Johns Hopkins University, Baltimore, MD, USA.
S SafrenDepartment of Psychology, University of Miami, Miami, FL, USA.ORCID 0000-0002-0121-0806
C O'CleirighDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-5639-5043
K CropseyDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
K H MayerDepartment of Medicine, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7460-733X
W C MathewsDepartment of Medicine, University of California, San Diego, CA, USA.
R D MooreDepartment of Medicine, Johns Hopkins University, Baltimore, MD, USA.
S NapravnikDepartment of Medicine, University of North Carolina, Chapel Hill, NC, USA.
K ChristopoulosDepartment of Medicine, University of California, San Francisco, CA, USA.
A WilligDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
J M JacobsonDepartment of Medicine, Case Western Reserve University, Cleveland, OH, USA.
A WebelDepartment of Child, Family, and Population Health Nursing, Unviersity of Washington, Seattle, WA, USA.
G BurkholderDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
M J MugaveroDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
M S SaagDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
M M KitahataDepartment of Medicine, University of Washington, Seattle, WA, USA.
H M CraneDepartment of Medicine, University of Washington, Seattle, WA, USA.
J A C DelaneyDepartment of Medicine, University of Washington, Seattle, WA, USA.
University of Washington · USUniversity of Alabama at Birmingham · USJohns Hopkins University · USHarvard University · USCase Western Reserve University · USUniversity of California San Diego · USUniversity of California, San Francisco · USUniversity of Miami · USUniversity of North Carolina at Chapel Hill · USUniversity of Toronto · CA

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
Unsolicited R24 for the CFAR-Network of Integrated Clinical Sciences, CNICSR24AI067039 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael S. Saag · 2006 to 2026
$99.4M
The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ARTHUR Y KIM · 2004 to 2026
$94.4M
Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1M
Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Anna Palmer Durbin · 2012 to 2026
$67.0M
WG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Immaculate Lillian Nankya · 1994 to 2026
$50.0M
Johns Hopkins HIV Clinical CohortU01DA036935 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MOORE, RICHARD DOUGLAS · 2014 to 2024
$14.9M
HOST DEFENSE TRAINING IN ALLERGY AND INFECTIOUS DISEASEST32AI007044 · NIAID · UNIVERSITY OF WASHINGTON · PI DAVID Neal FREDRICKS · 1985 to 2026
$14.6M
The University of Miami AIDS Research Center on Mental Health and HIV/AIDS - Center for HIV & Research in Mental Health (CHARM)Research Core & MHD-CEP30MH133399 · NIMH · UNIVERSITY OF MIAMI CORAL GABLES · PI Victoria Behar-Zusman · 2023 to 2026
$8.9M
Alcohol Research Consortium in HIV: Relapse Prevention ArmP01AA029544 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI HUTTON, HEIDI · 2021 to 2025
$7.1M
University of Miami Developmental HIV/AIDS Mental Health Research Center (D-ARC)P30MH116867 · NIMH · UNIVERSITY OF MIAMI CORAL GABLES · PI SAFREN, STEVEN A · 2019 to 2023
$6.5M
NIAAA NIH HHS K24 AA027483NIAAA NIH HHS P01 AA029544NIAAA NIH HHS U01 AA020793NIAAA NIH HHS U01 AA020802NIAAA NIH HHS U24 AA020801NIAID NIH HHS P30 AI027757NIAID NIH HHS P30 AI027763NIAID NIH HHS P30 AI027767NIAID NIH HHS P30 AI036219NIAID NIH HHS P30 AI094189NIAID NIH HHS R24 AI067039NIAID NIH HHS T32 AI007044NICHD NIH HHS P2C HD042828NIDA NIH HHS R01 DA047045NIDA NIH HHS R01 DA058938NIDA NIH HHS U01 DA036935NIMH NIH HHS P30 MH116867NIMH NIH HHS P30 MH133399
6 · The paper itself

Abstract

Substance use in people with HIV (PWH) negatively impacts antiretroviral therapy (ART) adherence. However, less is known about this in the current treatment era and the impact of specific substances or severity of substance use. We examined the associations of alcohol, marijuana, and illicit drug use (methamphetamine/crystal, cocaine/crack, illicit opioids/heroin) and their severity of use with adherence using multivariable linear regression in adult PWH in care between 2016 and 2020 at 8 sites across the US. PWH completed assessments of alcohol use severity (AUDIT-C), drug use severity (modified ASSIST), and ART adherence (visual analogue scale). Among 9400 PWH, 16% reported current hazardous alcohol use, 31% current marijuana use, and 15% current use of ≥1 illicit drugs. In multivariable analysis, current methamphetamine/crystal use, particularly common among men who had sex with men, was associated with 10.1% lower mean ART adherence (

Indexed as

HIV InfectionsIllicit DrugsMethamphetamineSubstance-Related DisordersAdultAnti-Retroviral AgentsEthanolHumansMaleMedication AdherenceAnti-Retroviral AgentsEthanolIllicit DrugsMethamphetamineadherencealcoholantiretroviral therapyARTmethamphetamineSubstance use

Identifiers

PMID37419138
PMCPMC10771542
OpenAlexW4383498304

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.