Evidence map›Paper›PMID 37419102›Full record

ArticleCell stem cell2023

Context matters: hPSC-derived microglia thrive in a humanized brain environment in vivo.

Jonas Cerneckis, Yanhong Shi

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Jonas CerneckisDepartment of Neurodegenerative Diseases, Beckman Research Institute of City of Hope, 1500 E. Duarte Rd, Duarte, CA 91010, USA.
Yanhong ShiDepartment of Neurodegenerative Diseases, Beckman Research Institute of City of Hope, 1500 E. Duarte Rd, Duarte, CA 91010, USA. Electronic address: yshi@coh.org.
City of Hope · USCity Of Hope National Medical Center · US

Funding

ApoE2 in Alzheimer's disease: the neuroprotective effects and mechanismsRF1AG061794 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI SHI, YANHONG · 2018 to 2018
$3.1M
Modeling Alzheimer’s disease using directly reprogrammed isogenic neural cellsR01AG056305 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI HUANG, YADONG, SHI, YANHONG · 2017 to 2021
$2.2M
Develop age-relevant glial cellular models using human directly reprogrammed cellsR01AG072291 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI SHI, YANHONG · 2021 to 2025
$2.2M
Define the effect of CLU SNP on the risk to Alzheimer's diseaseRF1AG079307 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI SHI, YANHONG · 2022 to 2022
$1.9M
NIA NIH HHS R01 AG056305NIA NIH HHS R01 AG072291NIA NIH HHS RF1 AG061794NIA NIH HHS RF1 AG079307
6 · The paper itself

Abstract

It remains challenging to create a physiologically relevant human-brain-like environment that would support maturation of human pluripotent stem cell (hPSC)-derived microglia (hMGs). Schafer et al.

Indexed as

MicrogliaPluripotent Stem CellsBrainCell DifferentiationHumans

Identifiers

PMID37419102
PMCPMC10505011
OpenAlexW4383314737

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.