ArticleSchizophrenia bulletin2023
Social Withdrawal, Loneliness, and Health in Schizophrenia: Psychological and Neural Mechanisms.
Article in Schizophrenia bulletin, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 39 citations in OpenAlex.
- Positive affect during social interactions predicts goal progress and social motivation in daily life for people with schizophrenia.Schizophrenia research · 2026Article
- Aging in Schizophrenia: Clinical, Biological, and Psychosocial Perspectives.Geriatrics (Basel, Switzerland) · 2026Review
- TALE and Hox Transcription Factors Modulate Adult Behaviors in Zebrafish.Behavior genetics · 2026Article
- Loneliness, Genetic Susceptibility, Brain Structure, and the Risk of Schizophrenia: A Large Prospective Study.Schizophrenia bulletin · 2026Article
- Loneliness in Schizophrenia: The Mediating Roles of Asocial Beliefs and Mattering.The International journal of social psychiatry · 2026Article
- "A room of one's own": Exploring the role of delusions and social isolation on disorganisation in thought disorder.Social psychiatry and psychiatric epidemiology · 2026Article
- Identifying Research Priorities in Early Psychosis: A Collaborative Approach to Shaping the Future of Early Psychosis Clinical Trials in Australia.Early intervention in psychiatry · 2026Article
- Psychosocial Factors Affecting Community Integration in Schizophrenia Patients: The Moderating Role of Perceived Policy Effectiveness.Brain and behavior · 2026Article
- TALE and Hox Transcription Factors Control Adult Behaviors in Zebrafish.bioRxiv : the preprint server for biology · 2026Article
- Factors Associated with Loneliness Among Older Adults Who Experienced Homelessness: Results from the HOPE HOME Study.Journal of general internal medicine · 2026Article
- An idiographic network approach to modeling daily loneliness and paranoia in psychosis: implications for personalized interventions.Frontiers in psychiatry · 2026Article
- A Qualitative Exploration of the Acceptability of a Supported Self-Management Intervention for People With Type 2 Diabetes and Severe Mental Illness.Journal of diabetes research · 2026Article
- Selective magnetic stimulation downregulates the GABAMolecular psychiatry · 2026Article
- Association between loneliness and hippocampal responses to dynamic social stimuli in psychotic disorders.Psychological medicine · 2025Article
- Loneliness in schizophrenia: Just loneliness.Annals of the New York Academy of Sciences · 2025Review
- Adaptation to colorectal cancer and ostomy: Psychological flexibility mitigates loneliness associated with social withdrawal.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Borderline Personality Disorder or First-Episode Psychosis? Challenges in Assessing Psychotic Features in Early Intervention: A Case Report.Early intervention in psychiatry · 2025Article
- Virtual reality-based versus standard cognitive behavioral therapy for paranoia in schizophrenia spectrum disorders: a randomized controlled trial.Nature medicine · 2025Article
- Disease duration-stratified associations of thyroid hormone levels with psychopathology in hospitalized patients with schizophrenia: A cross-sectional study.World journal of psychiatry · 2025Article
- Association Between Skeletal Muscle Mass Indices and Cognitive Function Among Inpatients With Stable Schizophrenia.Psychiatry investigation · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
background and hypothesisSome of the most debilitating aspects of schizophrenia and other serious mental illnesses (SMI) are the impairments in social perception, motivation, and behavior that frequently accompany these conditions. These impairments may ultimately lead to chronic social disconnection (ie, social withdrawal, objective isolation, and perceived social isolation or loneliness), which may contribute to the poor cardiometabolic health and early mortality commonly observed in SMI. However, the psychological and neurobiological mechanisms underlying relationships between impairments in social perception and motivation and social isolation and loneliness in SMI remain incompletely understood. STUDY
designA narrative, selective review of studies on social withdrawal, isolation, loneliness, and health in SMI. STUDY
resultsWe describe some of what is known and hypothesized about the psychological and neurobiological mechanisms of social disconnection in the general population, and how these mechanisms may contribute to social isolation and loneliness, and their consequences, in individuals with SMI.
conclusionsA synthesis of evolutionary and cognitive theories with the "social homeostasis" model of social isolation and loneliness represents one testable framework for understanding the dynamic cognitive and biological correlates, as well as the health consequences, of social disconnection in SMI. The development of such an understanding may provide the basis for novel approaches for preventing or treating both functional disability and poor physical health that diminish the quality and length of life for many individuals with these conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.