Evidence map›Paper›PMID 37418880›Full record

ArticleFood chemistry2023

Design and advanced characterization of quercetin-loaded nano-liposomes prepared by high-pressure homogenization.

Sofia Melchior, Marta Codrich, Andrea Gorassini, Dora Mehn, Jessica Ponti, Giancarlo Verardo, Gianluca Tell, Luigi Calzolai, Sonia Calligaris

Abstract read
In one paragraph

Article in Food chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  17. Formulation of silymarin surface modified vesicles: In vitro characterization to cell viability assessment.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sofia MelchiorDepartment of Agricultural, Food, Environmental and Animal Sciences, University of Udine, Udine, Italy. Electronic address: sofia.melchior@uniud.it.
Marta CodrichDepartment of Medicine, University of Udine, Udine, Italy.
Andrea GorassiniDepartment of Humanities and Cultural Heritage, University of Udine, Udine, Italy.
Dora MehnEuropean Commission, Joint Research Centre (JRC), Ispra, Italy.
Jessica PontiEuropean Commission, Joint Research Centre (JRC), Ispra, Italy.
Giancarlo VerardoDepartment of Agricultural, Food, Environmental and Animal Sciences, University of Udine, Udine, Italy.
Gianluca TellDepartment of Medicine, University of Udine, Udine, Italy.
Luigi CalzolaiEuropean Commission, Joint Research Centre (JRC), Ispra, Italy. Electronic address: luigi.calzolai@ec.europa.eu.
Sonia CalligarisDepartment of Agricultural, Food, Environmental and Animal Sciences, University of Udine, Udine, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quercetin-loaded nano-liposomes were prepared by high-pressure homogenization (HPH) at different pressures (up to 150 MPa) and number of passes (up to 3) to define the best processing conditions allowing the lowest particle size and the highest encapsulation efficiency (EE). The process at 150 MPa for 1 pass was the best, producing quercetin-loaded liposomes with the lowest particle size and 42% EE. Advanced techniques (multi-detector asymmetrical-flow field flow fractionation and analytical ultracentrifugation combined with transmission electron microscopy) were further used for the characterization of the liposomes which were oblong in shape (ca. 30 nm). Results highlight the need for several techniques to study nano-sized, polydisperse samples. The potential of quercetin-loaded liposomes against colon cancer cells was demonstrated. Results prove that HPH is an efficient and sustainable method for liposome preparation and highlight the remarkable role of process optimisation as well as the powerfulness of advanced methodologies for the characterisation of nano-structures.

Indexed as

LiposomesNanoparticlesMicroscopy, Electron, TransmissionParticle SizeQuercetinLiposomesQuercetinAdvanced analytical techniquesHigh-pressure homogenizationLiposomesNano-sized delivery system

Identifiers

PMID37418880
PMCPMC10410694

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.