ArticleScience advances2023
Spatially offset optical coherence tomography: Leveraging multiple scattering for high-contrast imaging at depth in turbid media.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Spatio-temporal optical coherence imaging and tomography forJournal of biomedical optics · 2026Review
- Monte Carlo OCT simulations investigating the effect of multiple scattered light on OCT-based attenuation coefficient quantification.Biomedical optics express · 2026Article
- Deep learning-enabled speckle reduction for cleared-sample coherent scattering tomography.bioRxiv : the preprint server for biology · 2026Article
- FUSION: A fast and uniform processing framework for whole-brain optical scattering tomography images.bioRxiv : the preprint server for biology · 2026Article
- Impact of Optical Coherence Tomography (OCT) for Periodontitis Diagnostics: Current Overview and Advances.Dentistry journal · 2025Review
- Enhanced penetration depth in optical coherence tomography and photoacoustic microscopyOptica · 2025Article
- Monte Carlo-based realistic simulation of optical coherence tomography angiography.Biomedical optics express · 2025Article
- Study of Time-Resolved Dynamics in Turbid Medium Using a Single-Cavity Dual-Comb Laser.ACS photonics · 2024Article
- Polarization-resolved analysis of outer retinal bands: investigating ballistic and multiply scattered photons using full-field swept-source optical coherence tomography.Biomedical optics express · 2024Article
- Viewing early life without labels: optical approaches for imaging the early embryo†.Biology of reproduction · 2024Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The penetration depth of optical coherence tomography (OCT) reaches well beyond conventional microscopy; however, signal reduction with depth leads to rapid degradation of the signal below the noise level. The pursuit of imaging at depth has been largely approached by extinguishing multiple scattering. However, in OCT, multiple scattering substantially contributes to image formation at depth. Here, we investigate the role of multiple scattering in OCT image contrast and postulate that, in OCT, multiple scattering can enhance image contrast at depth. We introduce an original geometry that completely decouples the incident and collection fields by introducing a spatial offset between them, leading to preferential collection of multiply scattered light. A wave optics-based theoretical framework supports our experimentally demonstrated improvement in contrast. The effective signal attenuation can be reduced by more than 24 decibels. Notably, a ninefold enhancement in image contrast at depth is observed in scattering biological samples. This geometry enables a powerful capacity to dynamically tune for contrast at depth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.