ArticlePLoS computational biology2023
Multiscale effects of excitatory-inhibitory homeostasis in lesioned cortical networks: A computational study.
Article in PLoS computational biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Preventing slowing down of alpha rhythms in stroke patients through modulation of cortical excitatory-inhibitory balance: a randomized controlled trial.Journal of neuroengineering and rehabilitation · 2026Trial
- A graph neural network approach to investigate brain critical states over neurodevelopment.Network neuroscience (Cambridge, Mass.) · 2025Article
- Neural signal analysis in chronic stroke: advancing intracortical brain-computer interface design.Frontiers in human neuroscience · 2025Article
- Metastable dynamics emerge from local excitatory-inhibitory homeostasis in the cortex at rest.Network neuroscience (Cambridge, Mass.) · 2025Article
- Excitatory-inhibitory homeostasis and bifurcation control in the Wilson-Cowan model of cortical dynamics.PLoS computational biology · 2025Article
- Role of homeostatic plasticity in critical brain dynamics following focal stroke lesions.Scientific reports · 2024Article
- Homeodynamic feedback inhibition control in whole-brain simulations.PLoS computational biology · 2024Article
- Multi-modal and multi-model interrogation of large-scale functional brain networks.NeuroImage · 2023Article
- Patient-specific modeling for guided rehabilitation of stroke patients: the BrainX3 use-case.Frontiers in neurology · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke-related disruptions in functional connectivity (FC) often spread beyond lesioned areas and, given the localized nature of lesions, it is unclear how the recovery of FC is orchestrated on a global scale. Since recovery is accompanied by long-term changes in excitability, we propose excitatory-inhibitory (E-I) homeostasis as a driving mechanism. We present a large-scale model of the neocortex, with synaptic scaling of local inhibition, showing how E-I homeostasis can drive the post-lesion restoration of FC and linking it to changes in excitability. We show that functional networks could reorganize to recover disrupted modularity and small-worldness, but not network dynamics, suggesting the need to consider forms of plasticity beyond synaptic scaling of inhibition. On average, we observed widespread increases in excitability, with the emergence of complex lesion-dependent patterns related to biomarkers of relevant side effects of stroke, such as epilepsy, depression and chronic pain. In summary, our results show that the effects of E-I homeostasis extend beyond local E-I balance, driving the restoration of global properties of FC, and relating to post-stroke symptomatology. Therefore, we suggest the framework of E-I homeostasis as a relevant theoretical foundation for the study of stroke recovery and for understanding the emergence of meaningful features of FC from local dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.