Evidence map›Paper›PMID 37418349›Full record

ReviewEpilepsia open2023

Epileptic seizures worsen the gait and motor abnormalities in adult patients with Dravet syndrome (with a case report and literature review).

Xiaoping Du, Shizhong Lian, Meizhen Sun, Ruilong Li, Huifang Wang, Xiaoping Yang, Huifen Wang, Xiaobin Zhang, Fengpeng Wang, Yi Yao and 1 more

Open access · goldAbstract readReviewCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Review in Epilepsia open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Xiaoping DuDepartment of Neurology, First Hospital of Shanxi Medical University, Taiyuan, China.ORCID 0000-0002-2644-9872
Shizhong LianDepartment of Neurosurgery, First Hospital of Shanxi Medical University, Taiyuan, China.
Meizhen SunDepartment of Neurology, First Hospital of Shanxi Medical University, Taiyuan, China.
Ruilong LiDepartment of Neurosurgery, First Hospital of Shanxi Medical University, Taiyuan, China.
Huifang WangDepartment of Neurology, First Hospital of Shanxi Medical University, Taiyuan, China.
Xiaoping YangDepartment of Neurology, First Hospital of Shanxi Medical University, Taiyuan, China.
Huifen WangDepartment of Neurology, First Hospital of Shanxi Medical University, Taiyuan, China.
Xiaobin ZhangEpilepsy Center, Xiamen Humanity Hospital Fujian Medical University, Xiamen, China.
Fengpeng WangEpilepsy Center, Xiamen Humanity Hospital Fujian Medical University, Xiamen, China.
Yi YaoEpilepsy Center, Xiamen Humanity Hospital Fujian Medical University, Xiamen, China.
Junhong GuoDepartment of Neurology, First Hospital of Shanxi Medical University, Taiyuan, China.
Shanxi Medical University · CNFujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dravet syndrome (DS), previously known as severe myoclonic epilepsy in infancy (SMEI), is considered the most serious "epileptic encephalopathy." Here, we present a man with a de novo SCN1A mutation who was diagnosed with DS at the age of 29. In addition to pharmaco-resistant seizures and cognitive delay, he also developed moderate to severe motor and gait problems, such as crouching gait and Pisa syndrome. Moreover, it deteriorated significantly following an epileptic seizure. The patient presented with severe flexion of the head and trunk in the sagittal plane and fulfilled the diagnostic criteria for camptocormia and antecollis. After a week, it spontaneously alleviated partially. We applied levodopa to the patient and had a good response. Functional Gait Assessment (FGA) was assessed at three different times: 4 days after the seizure, 1 week after the seizure, and after taking levodopa for 2 years. The results were 4, 12, and 19 points, respectively. We postulated that: (1) gait and motor deficits are somehow influenced by recurrent epileptic episodes;(2) the nigrostriatal dopamine system is involved. To our knowledge, we were the ones who first reported this phenomenon.

Indexed as

Epilepsies, MyoclonicEpilepsyAdultGaitHumansLevodopaMaleMutationNAV1.1 Voltage-Gated Sodium ChannelSeizuresLevodopaNAV1.1 Voltage-Gated Sodium Channelcrouching gaitDravet syndromegait disturbancesprognosisseizure

Identifiers

PMID37418349
PMCPMC10690644
OpenAlexW4383532348

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.