Evidence map›Paper›PMID 37418337›Full record

ArticleAnalytical chemistry2023

Enhancement of Lipid Signals in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry with Ammonium Fluoride as a Matrix Additive.

Joseph H Holbrook, Emily R Sekera, Arbil Lopez, Brian D Fries, Fernando Tobias, Kubra Akkaya, Maria M Mihaylova, Amanda B Hummon

Abstract read
In one paragraph

Article in Analytical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Quantitative mass spectrometry imaging: therapeutics & biomolecules.Chemical communications (Cambridge, England) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Joseph H HolbrookOhio State Biochemistry Program, The Ohio State University, Columbus, Ohio 43210, United States.
Emily R SekeraDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0002-1668-3227
Arbil LopezDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.
Brian D FriesDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.
Fernando TobiasDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0002-4085-4188
Kubra AkkayaDepartment of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, Ohio 43210, United States.
Maria M MihaylovaOhio State Biochemistry Program, The Ohio State University, Columbus, Ohio 43210, United States.
Amanda B HummonOhio State Biochemistry Program, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0002-1969-9013

Funding

Spatial SILAC: Examining the Proteome in 3D Cell CulturesR01GM110406 · NIGMS · UNIVERSITY OF NOTRE DAME · PI HUMMON, AMANDA B. · 2014 to 2022
$3.0M
Determining Age-Dependent Metabolic Changes in Tumors and Their MicroenvironmentDP2CA271361 · NCI · OHIO STATE UNIVERSITY · PI MIHAYLOVA, MARIA M. · 2021 to 2024
$2.3M
Electroblotting through enzymatic membranes to enhance MALDI tissue imaging of proteinsR21AG062144 · NIA · OHIO STATE UNIVERSITY · PI HUMMON, AMANDA B. · 2019 to 2020
$424k
NCI NIH HHS DP2 CA271361NIA NIH HHS R21 AG062144NIGMS NIH HHS R01 GM110406
6 · The paper itself

Abstract

Lipids are essential macromolecules that play a crucial role in numerous biological events. Lipids are structurally diverse which allows them to fulfill multiple functional roles. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a powerful tool to understand the spatial localization of lipids within biological systems. Herein, we report the use of ammonium fluoride (NH

Indexed as

FluoridesLipidsAmmonium CompoundsLasersProtonsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationAmmonium Compoundsammonium fluorideFluoridesLipidsProtons

Identifiers

PMID37418337
PMCPMC10655718

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.