Evidence map›Paper›PMID 37418317›Full record

ArticleACS biomaterials science & engineering2023

Biological Effects of New Titanium Surface Coatings Based on Ionic Liquids and HMGB1: A Cellular and Molecular Characterization in Lewis Rats.

Alexandra Arteaga, Claudia Cristina Biguetti, Bhuvana Lakkasetter Chandrashekar, Jimena Mora, Adeena Qureshi, Danieli C Rodrigues

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS biomaterials science & engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alexandra ArteagaDepartment of Bioengineering, The University of Texas at Dallas, Richardson 75080-3021, Texas, United States.ORCID 0000-0002-8610-5860
Claudia Cristina BiguettiDepartment of Surgery and Biomechanics, School of Podiatric Medicine, The University of Texas Rio Grande Valley, Harlingen 78539, Texas, United States.
Bhuvana Lakkasetter ChandrashekarDepartment of Bioengineering, The University of Texas at Dallas, Richardson 75080-3021, Texas, United States.
Jimena MoraDepartment of Bioengineering, The University of Texas at Dallas, Richardson 75080-3021, Texas, United States.
Adeena QureshiDepartment of Bioengineering, The University of Texas at Dallas, Richardson 75080-3021, Texas, United States.
Danieli C RodriguesDepartment of Bioengineering, The University of Texas at Dallas, Richardson 75080-3021, Texas, United States.ORCID 0000-0002-0389-0833
The University of Texas at Dallas · USThe University of Texas Rio Grande Valley · US

Funding

Understanding The Impact of Diabetes on Implant Performance: A Retrieval StudyF31DK121483 · NIDDK · UNIVERSITY OF TEXAS DALLAS · PI ARTEAGA, ALEXANDRA · 2019 to 2022
$163k
NIDDK NIH HHS F31 DK121483
6 · The paper itself

Abstract

High Mobility Group Box 1 (HMGB1) is a redox-sensitive molecule that plays dual roles in tissue healing and inflammation. We previously demonstrated that HMGB1 is stable when anchored by a well-characterized imidazolium-based ionic liquid (IonL), which serves as a delivery vehicle for exogenous HMGB1 to the site of injury and prevents denaturation from surface adherence. However, HMGB1 exists in different isoforms [fully reduced HMGB1 (FR), a recombinant version of FR resistant to oxidation (3S), disulfide HMGB1 (DS), and inactive sulfonyl HMGB1(SO)] that have distinct biological functions in health and disease. Thus, the goal of this study was to evaluate the effects of different recombinant HMGB1 isoforms on the host response using a rat subcutaneous implantation model. A total of 12 male Lewis rats (12-15 weeks) were implanted with titanium discs containing different treatments (

Indexed as

HMGB1 ProteinIonic LiquidsAnimalsAnti-Inflammatory AgentsMaleRatsRats, Inbred LewTitaniumAnti-Inflammatory AgentsHMGB1 ProteinIonic LiquidsTitaniumimmunomodulationimplant coatinginflammationsubcutaneous

Identifiers

PMID37418317
PMCPMC11292580
OpenAlexW4383532525

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.