ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2023
Sleep quality, fatigue, societal participation and health-related quality of life in kidney transplant recipients: a cross-sectional and longitudinal cohort study.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Self-Reported Sleep Duration After Kidney Transplantation Requires Medication-Aware Interpretation.Nephrology (Carlton, Vic.) · 2026Article
- French Translation and Psychometric Evaluation of the Standardized Outcomes in Nephrology Life Participation Instrument Among Kidney Transplant Recipients.Kidney international reports · 2026Article
- Sleep Hygiene Among People With CKD.Kidney international reports · 2026Article
- Sleep-Related Disorders in Patients with CKD and Kidney Transplant Recipients.Clinical journal of the American Society of Nephrology : CJASN · 2025Review
- Predicting Sleep Quality Based on Metabolic, Body Composition, and Physical Fitness Variables in Aged People: Exploratory Analysis with a Conventional Machine Learning Model.Journal of functional morphology and kinesiology · 2025Article
- TransplantLines, a biobank and cohort study of solid organ transplant recipients and donors.European journal of epidemiology · 2025Observational
- Assessing Social Participation Among Kidney Transplant Recipients Using PROMIS Computer Adaptive Testing.Kidney international reports · 2025Article
- Effect of Exercise or Combined Exercise and Diet Intervention on Sleep and Fatigue in Kidney Transplant Recipients.Kidney international reports · 2025Article
- Insights Into Health-Related Quality of Life of Kidney Transplant Recipients: A Narrative Review of Associated Factors.Kidney medicine · 2025Review
- Mineralocorticoid Receptor and Sleep Quality in Chronic Kidney Disease.International journal of molecular sciences · 2024Review
- The Effects of an 8-Month Multicomponent Training Program in Body Composition, Functional Fitness, and Sleep Quality in Aged People: A Randomized Controlled Trial.Journal of clinical medicine · 2024Article
- Correlation of objective and subjective sleep parameters with fatigue and depression in kidney transplant recipients.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Article
- The Heterogeneity of Symptom Burden and Fear of Progression Among Kidney Transplant Recipients: A Latent Class Analysis.Psychology research and behavior management · 2024Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFatigue and impaired health-related quality of life (HRQoL) are common among kidney transplant recipients (KTR). We hypothesized that both may partially be attributable to poor sleep.
methodsCross-sectional and longitudinal data of KTR enrolled in the TransplantLines Biobank and Cohort Study were used. Sleep quality was assessed using the Pittsburgh Sleep Quality Index questionnaire. Individual strength (i.e. a composite of fatigue, concentration, motivation and physical activity), societal participation and HRQoL were assessed using validated questionnaires.
resultsWe included 872 KTR (39% female, age 56 ± 13 years) and 335 healthy controls. In total, 33% of male KTR and 49% of female KTR reported poor sleep quality, which was higher compared with male and female healthy controls (19% and 28%, respectively, P < .001 for both). In logistic regression analyses, female sex, anxiety, active smoking, low protein intake, physically inactive lifestyle, low plasma magnesium concentration, using calcineurin inhibitors, not using mTOR inhibitors and using benzodiazepine agonists were associated with poor sleep quality. In adjusted linear regression analyses, poor sleep was strongly and independently associated with lower individual strength [standardized β (st.β) = 0.59, 95% confidence interval (CI) 0.45 to 0.74, P < .001], poorer societal participation (frequency: st.β = -0.17, 95% CI -0.32 to -0.01, P = .04; restrictions: st.β = -0.36, 95% CI -0.51 to -0.21, P < .001; satisfaction: st.β = -0.44, 95% CI -0.59 to -0.28, P < .001) and lower HRQoL (physical: st.β = -0.53, 95% CI -0.68 to -0.38, P < .001; mental: st.β = -0.64, 95% CI -0.78 to -0.50, P < .001). The associations with poorer societal participation and lower HRQoL were strongly mediated by individual strength (P < .001 for all), yet the suggested direct effects of poor sleep quality on HRQoL remained significant (Pphysical = .03, Pmental = .002). Longitudinal data of 292 KTR showed that sleep quality improves after kidney transplantation in males (P < .001), but not in females (P = .9).
conclusionsPoor sleep quality is common among KTR, and may be a potential target to improve fatigue, societal participation and HRQoL among KTR.
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