ArticleAdvances in experimental medicine and biology2023
The Aging Patterns of Brain Structure, Function, and Energy Metabolism.
Article in Advances in experimental medicine and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- Exploration of brain imaging biomarkers in subthreshold depression patients across different ages: an ALE meta-analysis based on MRI studies.BMC psychiatry · 2025Pooled it
- Frequency-Stratified Changes in BDNF, IGF-1, and Cognitive Screening Scores Following a 16-Week Hatha Yoga Program in Older Women: A Quasi-Experimental Study.Healthcare (Basel, Switzerland) · 2026Article
- Effects of Protein Intake on Cognitive Function in Chinese Older Adults: A 10-Year Follow-Up Study.Nutrients · 2025Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
The normal aging process brings changes in brain structure, function, and energy metabolism, which are presumed to contribute to the age-related decline in brain function and cognitive ability. This chapter aims to summarize the aging patterns of brain structure, function, and energy metabolism to distinguish them from the pathological changes associated with neurodegenerative diseases and explore protective factors in aging. We first described the normal atrophy pattern of cortical gray matter with age, which is negatively affected by some neurodegenerative diseases and is protected by a healthy lifestyle, such as physical exercise. Next, we summarized the main types of age-related white matter lesions, including white matter atrophy and hyperintensity. Age-related white matter changes mainly occurred in the frontal lobe, and white matter lesions in posterior regions may be an early sign of Alzheimer's disease. In addition, the relationship between brain activity and various cognitive functions during aging was discussed based on electroencephalography, magnetoencephalogram, and functional magnetic resonance imaging. An age-related reduction in occipital activity is coupled with increased frontal activity, which supports the posterior-anterior shift in aging (PASA) theory. Finally, we discussed the relationship between amyloid-β deposition and tau accumulation in the brain, as pathological manifestations of neurodegenerative disease and aging.
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