Evidence map›Paper›PMID 37418142›Full record

ArticleInternational journal of clinical oncology2023

Rac1 activation in oral squamous cell carcinoma as a predictive factor associated with lymph node metastasis.

Masae Yamazaki, Shoichi Sekikawa, Taiki Suzuki, Satoru Ogane, Kazuhiko Hashimoto, Aya Sasaki, Takeshi Nomura

Abstract read
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In one paragraph

Article in International journal of clinical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Masae YamazakiDepartment of Oral Oncology, Oral and Maxillofacial Surgery, Tokyo Dental College, Chiyoda, Japan. t.yamazakimasae@gmail.com.ORCID http://orcid.org/0000-0001-7141-2174
Shoichi SekikawaOral Cancer Center, Tokyo Dental College, Chiyoda, Japan.
Taiki SuzukiDepartment of Oral Oncology, Oral and Maxillofacial Surgery, Tokyo Dental College, Chiyoda, Japan.
Satoru OganeDepartment of Plastic, Oral and Maxillofacial Surgery, Teikyo University School of Medicine, Itabashi, Japan.
Kazuhiko HashimotoDepartment of Pathology and Laboratory Medicine, Ichikawa General Hospital, Tokyo Dental College, Chiyoda, Japan.
Aya SasakiDepartment of Pathology and Laboratory Medicine, Ichikawa General Hospital, Tokyo Dental College, Chiyoda, Japan.
Takeshi NomuraDepartment of Oral Oncology, Oral and Maxillofacial Surgery, Tokyo Dental College, Chiyoda, Japan.
Tokyo Dental College · JPTokyo Dental College Ichikawa General Hospital · JPTeikyo University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesSecondary lymph node metastasis (SLNM) indicates a poor prognosis, and limiting it can improve the survival rate in early-stage tongue squamous cell carcinoma (TSCC). Many factors have been identified as predictors of SLNM; however, there is no unified view. Ras-related C3 botulinum toxin substrate 1 (Rac1) was found to be a promoter of the epithelial-mesenchymal transition (EMT) and is also attracting attention as a new therapeutic target. This study aims to investigate the role of Rac1 in metastasis and its relationship with pathological findings in early-stage TSCC. MATERIALS AND

methodsRac1 expression levels of 69 cases of stage I/II TSCC specimens and their association with clinicopathological characteristics were evaluated by immunohistochemical staining. The role of Rac1 in oral squamous cell carcinoma (OSCC) was examined after Rac1 in OSCC cell lines was silenced in vitro.

resultsHigh Rac1 expression was significantly associated with the depth of invasion (DOI), tumor budding (TB), vascular invasion, and SLNM (p < 0.05). Univariate analyses revealed that Rac1 expression, DOI, and TB were factors significantly associated with SLNM (p < 0.05). Moreover, our multivariate analysis suggested that Rac1 expression was the only independent determinant of SLNM. An in vitro study revealed that Rac1 downregulation tended to decrease cell migration and proliferation.

conclusionRac1 was suggested to be an important factor in the metastasis of OSCC, and it could be useful as a predictor of SLNM.

Indexed as

rac1 GTP-Binding ProteinSquamous Cell Carcinoma of Head and NeckTongue NeoplasmsHumansLymphatic MetastasisNeoplasm InvasivenessPrognosisrac1 GTP-Binding ProteinRAC1 protein, humanCell migrationEpithelial–mesenchymal transitionOral squamous cell carcinomaRac1Secondary lymph node metastasis

Identifiers

PMID37418142
OpenAlexW4383483128

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.