Evidence map›Paper›PMID 37418117›Full record

ArticleAnnals of nuclear medicine2023

Diagnostic values of delayed additional FDG PET/CT scan in the evaluation of cardiac sarcoidosis.

Osamu Manabe, Keiko Takahashi, Hiroki Kawakami, Akira Ohtsuka, Tadao Aikawa, Hisataka Maki, Tatsuro Ibe, Hideo Fujita, Noriko Oyama-Manabe

Abstract read
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Article in Annals of nuclear medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. AI-enabled CT-guided end-to-end quantification of total cardiac activity in 18FDG cardiac PET/CT for detection of cardiac sarcoidosis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Osamu Manabe *Department of Radiology, Jichi Medical University Saitama Medical Center, 1-847 Amanuma-Cho, Omiya-Ku, Saitama, 330-8503, Japan.
Keiko Takahashi *Department of Radiology, Jichi Medical University Saitama Medical Center, 1-847 Amanuma-Cho, Omiya-Ku, Saitama, 330-8503, Japan.
Hiroki KawakamiCentral Division of Radiology, Jichi Medical University Saitama Medical Center, Saitama, Japan.
Akira OhtsukaCentral Division of Radiology, Jichi Medical University Saitama Medical Center, Saitama, Japan.
Tadao AikawaDepartment of Radiology, Jichi Medical University Saitama Medical Center, 1-847 Amanuma-Cho, Omiya-Ku, Saitama, 330-8503, Japan.
Hisataka MakiDepartment of Cardiovascular Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan.
Tatsuro IbeDepartment of Cardiovascular Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan.
Hideo FujitaDepartment of Cardiovascular Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan.
Noriko Oyama-ManabeDepartment of Radiology, Jichi Medical University Saitama Medical Center, 1-847 Amanuma-Cho, Omiya-Ku, Saitama, 330-8503, Japan. norikomanabe@jichi.ac.jp.ORCID http://orcid.org/0000-0002-0394-0095

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to compare the contribution of

methodsTwenty-three patients with CS (median age: 69 years; 11 women) were retrospectively evaluated using dual-phase FDG PET/CT. All patients were instructed to consume a low-carbohydrate diet followed by fasting for 18 h before FDG injection to reduce physiological myocardial uptake. PET/CT was acquired at 60 min (early) and 100 min (delayed) after FDG administration. Focal and focal on diffuse uptake on visual analysis was considered positive for CS. A semi-quantitative analysis was performed using the maximum standardized uptake value (SUVmax) of the cardiac lesion and the mean SUV (SUVmean) of the blood pool.

resultsSignificant myocardial FDG uptake was observed in 21 patients (91.3%) in the early acquisition group and in 23 patients in the delayed scan group (100%). Compared to the early scan, the delayed scan showed a significantly higher SUVmax of the cardiac lesion [median, 4.0; IQR (interquartile range, 2.9 to 7.0) vs. 5.8 (IQR 3.7 to 10.1); P = 0.0030] and a significantly lower SUVmean of blood pool [median, 1.3 (IQR, 1.2 to 1.4) vs. 1.1 (IQR, 0.9 to 1.2); P < 0.0001].

conclusionDelayed FDG PET/CT acquisition improves detection accuracy in patients with CS compared to early scans with washout of the blood pool activity. Therefore, it can contribute to a more accurate assessment of CS.

Indexed as

Positron Emission Tomography Computed TomographySarcoidosisAgedFemaleFluorodeoxyglucose F18HumansPositron-Emission TomographyRadiopharmaceuticalsRetrospective StudiesTomography, X-Ray ComputedFluorodeoxyglucose F18RadiopharmaceuticalsCardiac sarcoidosisDelayed scanFluorodeoxyglucosePositron emission tomography

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.