Evidence map›Paper›PMID 37418096›Full record

ArticleAMB Express2023

The leprosy reaction is associated with salivary anti-Porphyromonas gingivalis IgA antibodies.

Michelle Miranda Lopes Falcão, Johelle Santana Passos-Soares, Paulo Roberto Lima Machado, Isaac Suzart Gomes-Filho, Lucas Pedreira de Carvalho, Elisangela Jesus de Campos, Mariana Costa Calheira, Patrícia Mares de Miranda, Rebeca Pereira Bulhosa Santos, José Tadeu Raynal Rocha Filho and 5 more

Open access · goldAbstract read
In one paragraph

Article in AMB Express, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Michelle Miranda Lopes FalcãoDepartment of Health, State University of Feira de Santana, Feira de Santana, Brazil. mmlfalcao@uefs.br.ORCID http://orcid.org/0000-0002-0929-2324
Johelle Santana Passos-SoaresDepartment of Health, State University of Feira de Santana, Feira de Santana, Brazil.
Paulo Roberto Lima MachadoImmunology Service, University Hospital Prof. Edgar Santos Federal University of Bahia, Salvador, Brazil.
Isaac Suzart Gomes-FilhoDepartment of Health, State University of Feira de Santana, Feira de Santana, Brazil.
Lucas Pedreira de CarvalhoImmunology and Molecular Biology Laboratory, Federal University of Bahia, Salvador, Brazil.
Elisangela Jesus de CamposOral Biochemistry Laboratory, Health Sciences Institute, Federal University of Bahia, Salvador, Brazil.
Mariana Costa CalheiraPostgraduate Program in Immunology, Federal University of Bahia, Salvador, Brazil.
Patrícia Mares de MirandaPostgraduate Program in Immunology, Federal University of Bahia, Salvador, Brazil.
Rebeca Pereira Bulhosa SantosPostgraduate Program in Immunology, Federal University of Bahia, Salvador, Brazil.
José Tadeu Raynal Rocha FilhoImmunology and Molecular Biology Laboratory, Federal University of Bahia, Salvador, Brazil.
Antonio Pedro Froes de FariasPostgraduate Program in Immunology, Federal University of Bahia, Salvador, Brazil.
Taiana PeixotoSchool of Dentistry, Federal University of Bahia, Salvador, Brazil.
Roberto Meyer NascimentoImmunology and Molecular Biology Laboratory, Federal University of Bahia, Salvador, Brazil.
Gregory John SeymourSchool of Dentistry, The University of Queensland, Brisbane, Australia.
Soraya Castro TrindadeDepartment of Health, State University of Feira de Santana, Feira de Santana, Brazil.
Universidade Federal da Bahia · BRThe University of Queensland · AUUniversidade Estadual de Feira de Santana · BR

Funding

Fundação de Amparo à Pesquisa do Estado da Bahia Fundação de Amparo à Pesquisa do Estado da Bahia
6 · The paper itself

Abstract

The aim of the study was to evaluate the association between salivary anti-Porphyromonas gingivalis IgA antibodies and the leprosy reaction. The levels of salivary anti - P. gingivalis IgA antibodies, together with salivary flow and pH were measured in individuals diagnosed with leprosy and associated with the development of the leprosy reaction. Saliva was collected from 202 individuals diagnosed with leprosy at a reference leprosy treatment center, 106 cases with the leprosy reaction and 96 controls without the leprosy reaction. Anti - P. gingivalis IgA was evaluated by indirect immunoenzyme assay. Non-conditional logistic regression analysis was employed to estimate the association between antibody levels and the leprosy reaction. There was a positive statistically significant association between the levels of anti - P. gingivalis IgA and the presence of the leprosy reaction, controlling for confounders: age, sex, level of education and alcoholic beverage consumption: OR

Indexed as

Humoral responseLeprosyPeriodontitisSaliva

Identifiers

PMID37418096
PMCPMC10328877
OpenAlexW4383483801

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.