ArticlePediatric nephrology (Berlin, Germany)2023
Application of GFR estimating equations to children with normal, near-normal, or discordant GFR.
Article in Pediatric nephrology (Berlin, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Examining commonly used equations for estimating the glomerular filtration rate (GFR) in a healthy cohort of children and adolescents.BMC nephrology · 2026Observational
- Topological disruptions of metabolic brain networks in early-stage chronic kidney disease.BMC medical imaging · 2026Article
- Transition of patients with hereditary nephropathies from paediatric to adult care.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Article
- Measuring and estimating the GFR in children: state of the art in 2025.Pediatric nephrology (Berlin, Germany) · 2025Review
- An IQ Industry Perspective on Informing Dosing Recommendations in Patients With Renal Impairment.Clinical pharmacology and therapeutics · 2025Review
- Article
- Ideal rather than actual weight for glomerular filtration rate measurement: an issue to be clarified.Pediatric nephrology (Berlin, Germany) · 2024Article
- Evaluation of eGFR methods in a sub-Saharan African community-based pediatric population.Pediatric nephrology (Berlin, Germany) · 2024Article
- Application of the European Kidney Function Consortium Equation to Estimate Glomerular Filtration Rate: A Comparison Study of the CKiD and CKD-EPI Equations Using the Korea National Health and Nutrition Examination Survey (KNHANES 2008-2021).Medicina (Kaunas, Lithuania) · 2024Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective was to determine the extent that eGFR formulas correspond to measured plasma iohexol clearance (iGFR) in children with normal or near normal kidney function, particularly how different eGFR formulas yield discordant results.
methodsiGFR from 2 (iGFR-2pt) and 4 (iGFR-4pt) time points along with creatinine and/or cystatin C-based eGFR were measured in children with mild CKD, stages 1-2. eGFR was calculated using 6 equations: 3 under 25 (U25) formulas from the Chronic Kidney Disease in Children (CKiD) study, the full age-combined cystatin C (cysC) and creatinine spectrum (FAS-combined), the European Kidney Function Consortium (EKFC-creatinine) equation, and the Chronic Kidney Disease Epidemiology Collaboration (CKD-epi) cysC-based equation.
resultsTwenty-nine children were included, of which 22 had discordant creatinine vs. cystatin C-based eGFR by ≥ 15mL/min/1.73 m
conclusionThe formulas that most closely approximated the measured GFR varied depending on the pattern of discordant eGFR results. Based on the results, we recommend using the CKiD U25-combined formula to screen for children with a low GFR. Either the CKiD U25-combined or FAS-combined would be recommended for changes in eGFR longitudinally. However, because all formulas were discordant from the iGFR-4pt in over a third of participants, further refinement of pediatric eGFR formulas is needed at the normal/near-normal range. A higher resolution version of the Graphical abstract is available as Supplementary information.
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