Evidence map›Paper›PMID 37417889›Full record

ArticleProtein science : a publication of the Protein Society2023

Binding and transport of LPS occurs through the coordinated combination of an array of sites across the entire Escherichia coli LPS transport protein LptA.

Kathryn M Schultz, John R Schneider, Matthew A Fischer, Nicholas P Cina, Molly O Riegert, Dara W Frank, Candice S Klug

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein science : a publication of the Protein Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Residues within the LptC transmembrane helix are critical for Escherichia coli LptBProtein science : a publication of the Protein Society · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kathryn M SchultzDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
John R SchneiderDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Matthew A FischerDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Nicholas P CinaDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Molly O RiegertDepartment of Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Dara W FrankDepartment of Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Candice S KlugDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID 0000-0003-4547-320X
Medical College of Wisconsin · US

Funding

Lpt protein-mediated transport of LPSR01GM108817 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI KLUG, CANDICE S · 2014 to 2022
$2.6M
An Automated Microscale Thermophoresis Instrument for Southeastern Wisconsin: a Shared Resource for Biomolecular Interactions and Drug DiscoveryS10OD025036 · OD · MEDICAL COLLEGE OF WISCONSIN · PI HILL, R BLAKE · 2019 to 2019
$582k
NIGMS NIH HHS R01 GM108817NIH HHS S10 OD025036
6 · The paper itself

Abstract

The outer leaflet of the outer membrane (OM) of bacteria such as Escherichia coli, Pseudomonas aeruginosa, and other important pathogens is largely composed of lipopolysaccharide (LPS), which is essential to nearly all Gram-negative bacteria. LPS is transported to the outer leaflet of the OM through a yet unknown mechanism by seven proteins that comprise the LPS transport system. LptA, the only entirely periplasmic Lpt protein, bridges the periplasmic space between the IM LptB

Indexed as

Escherichia coliEscherichia coli ProteinsATP-Binding Cassette TransportersBacterial Outer Membrane ProteinsBiological TransportCarrier ProteinsLipopolysaccharidesATP-Binding Cassette TransportersBacterial Outer Membrane ProteinsCarrier ProteinsEscherichia coli ProteinsLipopolysaccharidesLptA protein, E coliLptB protein, E coliCD spectroscopylipopolysaccharideLPS transportLptAouter membrane biogenesisperiplasmic proteinprotein folding

Identifiers

PMID37417889
PMCPMC10360375
OpenAlexW4383483683

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.