Evidence map›Paper›PMID 37417819›Full record

ArticleOrganic & biomolecular chemistry2023

Deploying solid-phase synthesis to access thymine-containing nucleoside analogs that inhibit DNA repair nuclease SNM1A.

Christine A Arbour, Ellen M Fay, Joanna F McGouran, Barbara Imperiali

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic & biomolecular chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Christine A ArbourDepartment of Biology and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. imper@mit.edu.ORCID 0000-0001-6056-296X
Ellen M FaySchool of Chemistry and Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse St., Dublin 2, Ireland.ORCID 0000-0002-5442-5579
Joanna F McGouranSchool of Chemistry and Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse St., Dublin 2, Ireland.ORCID 0000-0002-9349-2141
Barbara ImperialiDepartment of Biology and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. imper@mit.edu.ORCID 0000-0002-5749-7869
Massachusetts Institute of Technology · USTrinity College Dublin · IE

Funding

Structure and function of the monotopic phosphoglycosyl transferase superfamily: Initiators of biosynthesis of complex bacterial glycoconjugatesR01GM131627 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ALLEN, KAREN N. · 2019 to 2025
$3.1M
Design and synthesis of nucleoside-based small molecules to inhibit phosphoglycosyl transferasesF32GM136023 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ARBOUR, CHRISTINE · 2020 to 2023
$234k
NIGMS NIH HHS F32 GM136023NIGMS NIH HHS R01 GM131627
6 · The paper itself

Abstract

Nucleoside analogs show useful bioactive properties. A versatile solid-phase synthesis that readily enables the diversification of thymine-containing nucleoside analogs is presented. The utility of the approach is demonstrated with the preparation of a library of compounds for analysis with SNM1A, a DNA damage repair enzyme that contributes to cytotoxicity. This exploration provided the most promising nucleoside-derived inhibitor of SNM1A to date with an IC

Indexed as

NucleosidesThymineDNA RepairExodeoxyribonucleasesSolid-Phase Synthesis TechniquesExodeoxyribonucleasesNucleosidesThymine

Identifiers

PMID37417819
PMCPMC10529636
OpenAlexW4382118112

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.