Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
8 authors at 3 institutions in 1 country.
Joseph B LinJohn F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine , St. Louis, Missouri, USA.ORCID 0000-0001-6667-9018
Amy MoraDepartment of Obstetrics & Gynecology, Washington University School of Medicine , St. Louis, Missouri, USA.
Tzu Jui WangJohn F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine , St. Louis, Missouri, USA.
Andrea SantefordJohn F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine , St. Louis, Missouri, USA.
Darksha UsmaniJohn F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine , St. Louis, Missouri, USA.
Marianne M LigonDepartment of Obstetrics & Gynecology, Washington University School of Medicine , St. Louis, Missouri, USA.
Indira U MysorekarDepartment of Obstetrics & Gynecology, Washington University School of Medicine , St. Louis, Missouri, USA.ORCID 0000-0003-3917-8677
Rajendra S ApteJohn F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine , St. Louis, Missouri, USA.ORCID 0000-0003-2281-2336
Washington University in St. Louis · USUniversity of Kentucky · USBaylor College of Medicine · US
Funding
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
NATIONAL RESEARCH SERVICE AWARD-MEDICAL SCIENTISTT32GM007200 · NIGMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1985 to 2024
$59.8M
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2M
WASHINGTON UNIVERSITY CENTER VISION RESEARCHP30EY002687 · NEI · WASHINGTON UNIVERSITY · PI Philip Raymond Williams · 1985 to 2026
$18.4M
Infectious Diseases/Basic Microbial Pathogenic MechanismsT32AI007172 · NIAID · WASHINGTON UNIVERSITY · PI Daniel E. Goldberg, JENNIFER A PHILIPS · 1985 to 2026
$13.0M
THE IMPORTANCE OF MACROPHAGE SENESCENCE IN REGULATING ANGIOGENESIS IN THE EYER01EY019287 · NEI · WASHINGTON UNIVERSITY · PI APTE, RAJENDRA S · 2010 to 2021
$3.9M
INTERLEUKIN-6 AND AGING: IMPACT ON IMMUNE DEFENSE AND TISSUE REPAIR IN URINARY BLADDERR01AG052494 · NIA · WASHINGTON UNIVERSITY · PI LOWDER, JERRY LANE, MYSOREKAR, INDIRA U · 2016 to 2020
$1.6M
Mechanism of age-associated inflammation and lymphoid neogenesis in the urinary bladderR56AG064634 · NIA · WASHINGTON UNIVERSITY · PI LOWDER, JERRY LANE, MYSOREKAR, INDIRA U · 2019 to 2019
$625k
Molecular and neuro-inflammatory biology of aging bladder in normal and disease states: ProjectP20DK119840 · NIDDK · WASHINGTON UNIVERSITY · PI MYSOREKAR, INDIRA U · 2018 to 2019
$612k
Role of stearoyl-CoA desaturase 2 in macrophage-mediated antimicrobial immunityF30DK130282 · NIDDK · WASHINGTON UNIVERSITY · PI LIN, JOSEPH B · 2021 to 2023
Macrophages are innate immune cells that patrol tissues and are the first responders to detect infection. They orchestrate the host immune response in eliminating invading pathogens and the subsequent transition from inflammation to tissue repair. Macrophage dysfunction contributes to age-related pathologies, including low-grade inflammation in advanced age that is termed "inflammaging." Our laboratory has previously identified that macrophage expression of a fatty acid desaturase, stearoyl-CoA desaturase 2 (SCD2), declines with age. Herein, we delineate the precise cellular effects of SCD2 deficiency in murine macrophages. We found that deletion of
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Loss of stearoyl-CoA desaturase 2 disrupts inflammatory response in macrophages. · full record | OpenQuestion