Evidence map›Paper›PMID 37417544›Full record

ArticleACS infectious diseases2023

Structure-Property Optimization of a Series of Imidazopyridines for Visceral Leishmaniasis.

Maria Dichiara, Quillon J Simpson, Antonio Quotadamo, Hitesh B Jalani, Anson X Huang, Caroline C Millard, Dana M Klug, Edwin G Tse, Matthew H Todd, Daniel Gedder Silva and 10 more

Abstract read
In one paragraph

Article in ACS infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Imidazo[1,2-ACS omega · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Maria DichiaraDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.ORCID 0000-0001-6380-7176
Quillon J SimpsonDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Antonio QuotadamoDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Hitesh B JalaniDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.ORCID 0000-0002-2442-9798
Anson X HuangDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Caroline C MillardDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Dana M KlugSchool of Pharmacy, University College London, London WC1N 1AX, U.K.
Edwin G TseSchool of Pharmacy, University College London, London WC1N 1AX, U.K.ORCID 0000-0002-9133-9274
Matthew H ToddSchool of Pharmacy, University College London, London WC1N 1AX, U.K.ORCID 0000-0001-7096-4751
Daniel Gedder SilvaSchool of Pharmacy, University College London, London WC1N 1AX, U.K.ORCID 0000-0001-8879-456X
Flavio da Silva EmerySchool of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo 14040-903, Brazil.ORCID 0000-0002-8652-7123
J Eric CarlsonRilas Technologies, Inc, 150-W New Boston Street, Woburn, Massachusetts 01801, United States.
Shao-Liang ZhengDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States.ORCID 0000-0002-6432-9943
Margot VleminckxLaboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, 2610 Wilrijk, Belgium.
An MatheeussenLaboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, 2610 Wilrijk, Belgium.
Guy CaljonLaboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, 2610 Wilrijk, Belgium.
Michael P PollastriDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.ORCID 0000-0001-9943-7197
Peter SjöDrugs for Neglected Diseases Initiative, 15 Chemin Camille Vidart, Geneva 1202, Switzerland.
Benjamin PerryDrugs for Neglected Diseases Initiative, 15 Chemin Camille Vidart, Geneva 1202, Switzerland.ORCID 0000-0001-6715-4213
Lori FerrinsDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.ORCID 0000-0001-8992-0919

Funding

Lead optimization of hits identified from virtual and experimental screens of multiple industrial libraries DNDiR33AI141227 · NIAID · NORTHEASTERN UNIVERSITY · PI FERRINS, LORI · 2021 to 2023
$1.2M
NIAID NIH HHS R33 AI141227
6 · The paper itself

Abstract

Leishmaniasis is a collection of diseases caused by more than 20

Indexed as

LeishmaniaLeishmaniasisLeishmaniasis, VisceralHumansImidazolesNeglected DiseasesPyridinesImidazolesimidazopyridinePyridinesleishmaniasisneglected tropical diseasesstructure−property optimization

Identifiers

PMID37417544
PMCPMC10425983

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.