Evidence map›Paper›PMID 37416876›Full record

ArticlePNAS nexus2023

Cyclic anthraquinone derivatives, unique G-quadruplex binders, selectively induce cancer cell apoptosis and inhibit tumor growth.

Hikaru Fukuda, Tingting Zou, Satoshi Fujii, Shinobu Sato, Daiki Wakahara, Sen Higashi, Ting-Yuan Tseng, Ta-Chau Chang, Naomi Yada, Kou Matsuo and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PNAS nexus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hikaru FukudaDivision of Applied Pharmacology, Department of Health Promotion, Kyushu Dental University, Fukuoka 803-8580, Japan.ORCID https://orcid.org/0009-0005-4811-0051
Tingting ZouDepartment of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan.ORCID https://orcid.org/0009-0006-6924-3758
Satoshi FujiiDepartment of Bioscience and Bioinformatics, Kyushu Institute of Technology, Fukuoka 820-8502, Japan.ORCID https://orcid.org/0000-0002-3341-8644
Shinobu SatoDepartment of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan.ORCID https://orcid.org/0000-0002-3813-0535
Daiki WakaharaDepartment of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan.
Sen HigashiDivision of Applied Pharmacology, Department of Health Promotion, Kyushu Dental University, Fukuoka 803-8580, Japan.
Ting-Yuan TsengInstitute of Atomic and Molecular Sciences, Academia Sinica, Taipei 10617, Taiwan.
Ta-Chau ChangInstitute of Atomic and Molecular Sciences, Academia Sinica, Taipei 10617, Taiwan.ORCID https://orcid.org/0000-0001-5878-8556
Naomi YadaDivision of Oral Pathology, Department of Health Promotion, Kyushu Dental University, Fukuoka 803-8580, Japan.
Kou MatsuoDivision of Oral Pathology, Department of Health Promotion, Kyushu Dental University, Fukuoka 803-8580, Japan.
Manabu HabuDivision of Oral and Maxillofacial Surgery, Department of Science of Physical Functions, Kyushu Dental University, Fukuoka 803-8580, Japan.
Kazuhiro TominagaDivision of Oral and Maxillofacial Surgery, Department of Science of Physical Functions, Kyushu Dental University, Fukuoka 803-8580, Japan.
Hiroshi TakeuchiDivision of Applied Pharmacology, Department of Health Promotion, Kyushu Dental University, Fukuoka 803-8580, Japan.ORCID https://orcid.org/0000-0003-0033-2913
Shigeori TakenakaDepartment of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan.ORCID https://orcid.org/0000-0003-3819-7673

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cyclic anthraquinone derivatives (cAQs), which link two side chains of 1,5-disubstituted anthraquinone as a threading DNA intercalator, have been developed as G-quartet (G4) DNA-specific ligands. Among the cAQs, cAQ-mBen linked through the 1,3-position of benzene had the strongest affinity for G4 recognition and stabilization in vitro and was confirmed to bind to the G4 structure in vivo, selectively inhibiting cancer cell proliferation in correlation with telomerase expression levels and triggering cell apoptosis. RNA-sequencing analysis further indicated that differentially expressed genes regulated by cAQ-mBen were profiled with more potential quadruplex-forming sequences. In the treatment of the tumor-bearing mouse model, cAQ-mBen could effectively reduce tumor tissue and had less adverse effects on healthy tissue. These results suggest that cAQ-mBen can be a potential cancer therapeutic agent as a G4 binder.

Indexed as

antitumor agentcancercyclic anthraquinone derivativesquadruplexxenograft

Identifiers

PMID37416876
PMCPMC10319625

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.