ArticleJournal of oral microbiology2023
Inhibition of biofilm formation and virulence factors of cariogenic oral pathogen
Article in Journal of oral microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 28 citations in OpenAlex.
- Apple phenolic compounds enhance dental remineralization in human: a multifactorial in situ study.Journal of advanced research · 2026Trial
- Anti-Cariogenic Potential of Lyophilized Cell-Free Supernatant of ProbioticJournal of microbiology and biotechnology · 2026Article
- In Vitro Antibacterial and Antibiofilm Effects of Antiseptics and Mouthwashes onPathogens (Basel, Switzerland) · 2026Article
- The Inhibition of Streptococcus mutans Biofilms following Exposure to Different Chocolate Ingredients.European journal of dentistry · 2026Article
- The Multifaceted Mechanistic Actions of Antimicrobial Nanoformulations: Overcoming Resistance and Enhancing Efficacy.Pharmaceutics · 2026Review
- Polyphenolic compounds inFrontiers in pharmacology · 2026Review
- Funoran as a marine anti-biofilm polysaccharide for caries prevention: biological basis, current evidence, and translational challenges.Frontiers in microbiology · 2026Review
- Article
- Antibacterial effect of a dental adhesive containing SCH-79797 onFrontiers in cellular and infection microbiology · 2026Article
- Disruption of quorum sensing and biofilm formation in Pseudomonas aeruginosa by plant-based O-methylated flavonoids.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Review
- Transcriptome analysis of tilapia streptococcus agalactiae in response to baicalin.Genes & genomics · 2025Article
- Case Report: Multidisciplinary management of a rare labial-palatal dual developmental groove with malocclusion: a 4-year follow-up.Frontiers in oral health · 2025Article
- Article
- Understanding Quorum-Sensing and Biofilm Forming in Anaerobic Bacterial Communities.International journal of molecular sciences · 2024Review
- Quorum Quenching Approaches against Bacterial-Biofilm-Induced Antibiotic Resistance.Antibiotics (Basel, Switzerland) · 2024Review
- The Anti-Biofilm Properties of Phloretin and Its Analogs againstFoods (Basel, Switzerland) · 2024Article
- Tetracyclic homoisoflavanoid (+)-brazilin: a natural product inhibits c-di-AMP-producing enzyme andMicrobiology spectrum · 2024Article
- Herbal Composite Preparation and Investigating its Efficiency to Inhibit Biofilm Formation and Virulence Factors ofJournal of pharmacy & bioallied sciences · 2024Article
- Inhibitory effect ofFrontiers in microbiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To evaluate the effect and mechanism of action of the flavonoid phloretin on the growth and sucrose-dependent biofilm formation of Methods: Minimum inhibitory concentration, viability, and biofilm susceptibility assays were conducted to assess antimicrobial and antibiofilm effect of phloretin. Biofilm composition and structure were analysed with scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). Water-soluble (WSG) and water-insoluble glucan (WIG) were determined using anthrone method. Lactic acid measurements and acid tolerance assay were performed to assess acidogenicity and aciduricity. Reverse transcription quantitative PCR (RT-qPCR) was used to measure the expression of virulence genes essential for surface attachment, biofilm formation, and quorum sensing. Results: Phloretin inhibited Conclusions: Phloretin exhibits antibacterial properties against Clinical significance: Phloretin is a promising natural compound with pronounced inhibitory effect on key virulence factors of the cariogenic pathogen,
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.