Evidence map›Paper›PMID 37416713›Full record

ArticleChemical science2023

Local solvation structures govern the mixing thermodynamics of glycerol-water solutions.

Debasish Das Mahanta, Dennis Robinson Brown, Simone Pezzotti, Songi Han, Gerhard Schwaab, M Scott Shell, Martina Havenith

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 39 citations in OpenAlex.

  1. A water-pinning hotspot drives templated tau aggregation.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Water-mediated hydrogen bonds and local side-chain interactions in the cooperative collapse and expansion of PNIPAM oligomers.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Hydraulic Activation of the AsLOV2 Photoreceptor.bioRxiv : the preprint server for biology · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Debasish Das MahantaLehrstuhl für Physikalische Chemie II, Ruhr-Universität Bochum 44780 Bochum Germany Martina.Havenith@ruhr-uni-bochum.de.ORCID https://orcid.org/0000-0002-6226-9545
Dennis Robinson BrownDepartment of Chemical Engineering, University of California Santa Barbara California 93106-5080 USA shell@ucsb.edu.
Simone PezzottiLehrstuhl für Physikalische Chemie II, Ruhr-Universität Bochum 44780 Bochum Germany Martina.Havenith@ruhr-uni-bochum.de.
Songi HanDepartment of Chemical Engineering, University of California Santa Barbara California 93106-5080 USA shell@ucsb.edu.
Gerhard SchwaabLehrstuhl für Physikalische Chemie II, Ruhr-Universität Bochum 44780 Bochum Germany Martina.Havenith@ruhr-uni-bochum.de.ORCID https://orcid.org/0000-0003-2136-907X
M Scott ShellDepartment of Chemical Engineering, University of California Santa Barbara California 93106-5080 USA shell@ucsb.edu.
Martina HavenithLehrstuhl für Physikalische Chemie II, Ruhr-Universität Bochum 44780 Bochum Germany Martina.Havenith@ruhr-uni-bochum.de.ORCID https://orcid.org/0000-0001-8475-5037
University of California, Santa Barbara · USRuhr University Bochum · DETU Dortmund University · DE

Funding

Water as essential building blocks to direct protein structure and functionR35GM136411 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Songi Han · 2020 to 2026
$2.4M
NIGMS NIH HHS R35 GM136411
6 · The paper itself

Abstract

Glycerol is a major cryoprotective agent and is widely used to promote protein stabilization. By a combined experimental and theoretical study, we show that global thermodynamic mixing properties of glycerol and water are dictated by local solvation motifs. We identify three hydration water populations,

Identifiers

PMID37416713
PMCPMC10321518
OpenAlexW4380986760

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.