Evidence map›Paper›PMID 37416635›Full record

ArticleHeliyon2023

Mitochondrial citrate accumulation triggers senescence of alveolar epithelial cells contributing to pulmonary fibrosis in mice.

Jie-Ru Hong, Ling Jin, Chen-Yu Zhang, Wen-Jing Zhong, Hui-Hui Yang, Guan-Ming Wang, Sheng-Chao Ma, Cha-Xiang Guan, Qing Li, Yong Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jie-Ru HongDepartment of Physiology, School of Basic Medical Science, Central South University, Changsha, Hunan 410078, China.
Ling JinDepartment of Physiology, School of Basic Medical Science, Central South University, Changsha, Hunan 410078, China.
Chen-Yu ZhangDepartment of Physiology, School of Basic Medical Science, Central South University, Changsha, Hunan 410078, China.
Wen-Jing ZhongDepartment of Physiology, School of Basic Medical Science, Central South University, Changsha, Hunan 410078, China.
Hui-Hui YangDepartment of Physiology, School of Basic Medical Science, Central South University, Changsha, Hunan 410078, China.
Guan-Ming WangDepartment of Physiology, School of Basic Medical Science, Central South University, Changsha, Hunan 410078, China.
Sheng-Chao MaNHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan 750004, China.
Cha-Xiang GuanDepartment of Physiology, School of Basic Medical Science, Central South University, Changsha, Hunan 410078, China.
Qing LiDepartment of Physiology, Hunan University of Medicine, Huaihua, Hunan 418000, China.
Yong ZhouDepartment of Physiology, School of Basic Medical Science, Central South University, Changsha, Hunan 410078, China.
Central South University · CNHunan University · CNNingxia Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alveolar epithelial cell (AEC) senescence is implicated in the pathogenesis of pulmonary fibrosis (PF). However, the exact mechanism underlying AEC senescence during PF remains poorly understood. Here, we reported an unrecognized mechanism for AEC senescence during PF. We found that, in bleomycin (BLM)-induced PF mice, the expressions of isocitrate dehydrogenase 3α (Idh3α) and citrate carrier (CIC) were significantly down-regulated in the lungs, which could result in mitochondria citrate (citrate

Indexed as

Alveolar epithelial cellCitratemt accumulationMitochondrial biogenesisPulmonary fibrosisSenescence

Identifiers

PMID37416635
PMCPMC10320039
OpenAlexW4381248849

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.